ArticleBMC musculoskeletal disorders2014
Immature articular cartilage and subchondral bone covered by menisci are potentially susceptive to mechanical load.
Article in BMC musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Restoring articular cartilage: insights from structure, composition and development.Nature reviews. Rheumatology · 2025Review
- Tissue growth as a mechanism for collagen fiber alignment in articular cartilage.Scientific reports · 2024Article
- Aligned Ice Templated Biomaterial Strategies for the Musculoskeletal System.Advanced healthcare materials · 2023Review
- Morphological and mechanical alterations in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs.Frontiers in bioengineering and biotechnology · 2023Article
- Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-κB ligand pathway in rabbits with knee osteoarthritis induced by modified Videman method.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Physiological Reloading Recovers Histologically Disuse Atrophy of the Articular Cartilage and Bone by Hindlimb Suspension in Rat Knee Joint.Cartilage · 2021Article
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- An animal model study on the gene expression profile of meniscal degeneration.Scientific reports · 2020Article
- MR imaging pattern of tibial subchondral bone structure: considerations of meniscal coverage and integrity.Skeletal radiology · 2020Article
- A degenerative medial meniscus retains some protective effect against osteoarthritis-induced subchondral bone changes.Bone reports · 2020Article
- Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces.Scientific reports · 2018Article
- Influence of meniscus on cartilage and subchondral bone features of knees from older individuals: A cadaver study.PloS one · 2017Article
- Characterization of nano-structural and nano-mechanical properties of osteoarthritic subchondral bone.BMC musculoskeletal disorders · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe differences of mechanical and histological properties between cartilage covered by menisci and uncovered by menisci may contribute to the osteoarthritis after meniscectomy and these differences are not fully understood. The purpose of this study is to investigate potential differences in the mechanical and histological properties, and in particular the collagen architecture, of the superficial cartilage layer and subchondral bone between regions covered and uncovered by menisci using immature knee.
methodsOsteochondral plugs were obtained from porcine tibial cartilage that was either covered or uncovered by menisci. Investigation of the thickness, mechanical properties, histology, and water content of the cartilage as well as micro-computed tomography analysis of the subchondral bone was performed to compare these regions. Collagen architecture was also assessed by using scanning electron microscopy.
resultsCompared to the cartilage uncovered by menisci, that covered by menisci was thinner and showed a higher deformity to compression loading and higher water content. In the superficial layer of cartilage in the uncovered regions, collagen fibers showed high density, whereas they showed low density in covered regions. Furthermore, subchondral bone architecture varied between the 2 regions, and showed low bone density in covered regions.
conclusionsCartilage covered by menisci differed from that uncovered in both its mechanical and histological properties, especially with regards to the density of the superficial collagen layer. These regional differences may be related to local mechanical environment in normal condition and indicate that cartilage covered by menisci is tightly guarded by menisci from extreme mechanical loading. Our results indicate that immature cartilage degeneration and subchondral microfracture may occur easily to extreme direct mechanical loading in covered region after meniscectomy.
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