ArticleActa veterinaria Scandinavica2014
Reduced birth weight, cleft palate and preputial abnormalities in a cloned dog.
Article in Acta veterinaria Scandinavica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Dead or Alive? A Review of Perinatal Factors That Determine Canine Neonatal Viability.Animals : an open access journal from MDPI · 2022Review
- Brachygnathia Inferior in Cloned Dogs Is Possibly Correlated with Variants of Wnt Signaling Pathway Initiators.International journal of molecular sciences · 2022Article
- Computed tomographic evaluation of cleft palate in one-day-old puppies.BMC veterinary research · 2018Article
- Health and temperaments of cloned working dogs.Journal of veterinary science · 2018Review
- Is cloning horses ethical?Equine veterinary education · 2018Review
- Welfare in horse breeding.The Veterinary record · 2015Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to report a novel developmental abnormality in a cloned dog. A fibroblast cell line was established from an 8-year-old male German shepherd dog. In vivo matured oocytes were retrieved from a large breed dog, and the nucleus was removed from each oocyte. A donor cell was injected into an enucleated oocyte, and the oocyte-cell couplet was fused electrically. After chemical activation, the resulting embryos were transferred into a naturally estrus-synchronized recipient dog, and two cloned pups were delivered by Cesarean section 60 days later. One cloned pup (Clone 1) was healthy, but the other (Clone 2) had a birth weight of only 320 g and cleft palate, failure of preputial closure at the ventral distal part, and persistent penile frenulum. Clone 2 was raised by stomach feeding until Day 40 after birth, where palatoplasty was performed. The abnormalities in external genitalia in Clone 2 resulted in persistent penile extrusion that was surgically corrected. This complex developmental abnormality has not been reported in dogs previously.
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Registered trials
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