ReviewAnnals of medical and health sciences research2014
Maternal and fetal Acid-base chemistry: a major determinant of perinatal outcome.
Review in Annals of medical and health sciences research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02862925 (Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts in Egypt.BMC pregnancy and childbirth · 2025Pooled it
- Trial
- Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance.British journal of anaesthesia · 2015Trial
- The impact of perioperative fasting on metabolic status in elective caesarean section patients.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Observational
- Fetal pHocus: A Novel Approach to Non-Invasive Fetal Arterial Blood pH Assessment via Near-Infrared Spectroscopy.ACM transactions on computing for healthcare · 2026Article
- Evaluating acid–base status and perfusion: arterial and venous blood gases during pregnancyRevista colombiana de obstetricia y ginecologia · 2026Article
- Effects of Molybdenum Supplementation in the Form of Ammonium and Sodium Salts on Trophoblast Cell Physiology and Gene Expression In Vitro.Journal of developmental biology · 2025Article
- Emergency cesarean section in pregnant trauma patients presenting after motor vehicle collision.Heliyon · 2024Article
- Relationship between maternal arterial and foetal cord carbon dioxide tension and neonatal outcome in critically ill pregnant women at delivery.Indian journal of anaesthesia · 2024Article
- Initial experience with the anaesthetic management of fetoscopic spina bifida repair at a German University Hospital: A case series of 15 patients.European journal of anaesthesiology and intensive care · 2024Review
- Sow Nutrition, Uterine Contractions, and Placental Blood Flow during the Peri-Partum Period and Short-Term Effects on Offspring: A Review.Animals : an open access journal from MDPI · 2023Review
- High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study.International journal of environmental research and public health · 2023Article
- Multiple electrolyte derangements among perioperative women with obstructed labour in eastern Uganda: A cross-sectional study.PLOS global public health · 2023Article
- Considering the Effects and Maternofoetal Implications of Vascular Disorders and the Umbilical Cord.Medicina (Kaunas, Lithuania) · 2022Review
- Using Pen-Side Measurable Blood Parameters to Predict or Identify Dystocic Lambing Events.Biology · 2022Article
- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update.Advances in experimental medicine and biology · 2022Article
- Cardiotocography analysis by empirical dynamic modeling and Gaussian processes.Frontiers in bioengineering and biotechnology · 2022Article
- Placenta in the Critically Ill Mother.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model.Biomedicines · 2021Article
- Mild Neonatal Acidemia is Associated with Neonatal Morbidity at Term.American journal of perinatology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Very small changes in pH may significantly affect the function of various fetal organ systems, such as the central nervous system, and the cardiovascular system with associated fetal distress and poor Apgar score. Review of existing data on maternal-fetal acid-base balance in pregnancy highlight the factors that are associated with derangements of the acid-base status and the impact of the derangements on fetal outcome. Extensive search of electronic databases and manual search of journals for relevant literature on maternal and fetal acid chemistry, clinical studies and case studies were undertaken. There is a substantial reduction in the partial pressure of carbon dioxide (pCO2) in pregnancy. Adequate buffering prevents significant changes in maternal arterial pH. Normal fetal metabolism results in the production of acids which are buffered to maintain extracellular pH within a critical range. Fetal hypoxia can occur when maternal oxygenation is compromised, maternal perfusion of the placenta is reduced, or delivery of oxygenated blood from the placenta to the fetus is impeded. When adequate fetal oxygenation does not occur, metabolisms proceed along with an anaerobic pathway with production of organic acids, such as lactic acid. Accumulation of lactic acid can deplete the buffer system and result in metabolic acidosis with associated low fetal pH, fetal distress and poor Apgar score. There is a significant reduction in pCO2 in pregnancy. This change, however, does not result in a corresponding significant reduction in maternal arterial pH, because of adequate buffering. Very small changes in pH may cause significant derangement in fetal function and outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.