Evidence map›Paper›PMID 24669291›Full record

ReviewWorld journal of cardiology2014

Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era.

Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez, Russel J Reiter

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Effects of histidine and vitamin C on isoproterenol-induced acute myocardial infarction in rats.Veterinary research forum : an international quarterly journal · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alberto Dominguez-RodriguezAlberto Dominguez-Rodriguez, Department of Cardiology, Complejo Hospitalario Universitario de Canarias, 38320 Tenerife, Spain.
Pedro Abreu-GonzalezAlberto Dominguez-Rodriguez, Department of Cardiology, Complejo Hospitalario Universitario de Canarias, 38320 Tenerife, Spain.
Russel J ReiterAlberto Dominguez-Rodriguez, Department of Cardiology, Complejo Hospitalario Universitario de Canarias, 38320 Tenerife, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results in additional damage, also known as myocardial ischemia-reperfusion injury. An improved understanding of the pathophysiological mechanisms underlying reperfusion injury has resulted in the identification of several promising pharmacological (cyclosporin-A, exenatide, glucose-insulin-potassium, atrial natriuretic peptide, adenosine, abciximab, erythropoietin, metoprolol and melatonin) therapeutic strategies for reducing the severity of myocardial reperfusion injury. Many of these agents have shown promise in initial proof-of-principle clinical studies. In this article, we review the pathophysiology underlying myocardial reperfusion injury and highlight the potential pharmacological interventions which could be used in the future to prevent reperfusion injury and improve clinical outcomes in patients with coronary heart disease.

Indexed as

Adjunctive therapyCardioprotectionInfarct sizeMyocardial reperfusion injuryST-elevation myocardial infarction

Identifiers

PMID24669291
PMCPMC3964186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.