ArticleOxidative medicine and cellular longevity2014
Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 55 citations in OpenAlex.
- Sex dimorphism in the cardiovascular responses to d-galactose-induced accelerated aging: effects of HO-1 modulation.GeroScience · 2026Article
- Investigating the protective and therapeutic potential of new generation antioxidant combinations in the brain: an experimental aging model.Biogerontology · 2026Article
- Redox-Immune Axis and Ozone Pollution: From Oxidative Stress to Thymic Involution and Neurodegeneration.Medical sciences (Basel, Switzerland) · 2025Review
- Preparation ofLife (Basel, Switzerland) · 2025Article
- Assessment ofFrontiers in nutrition · 2023Article
- Cacao powder supplementation attenuates oxidative stress, cholinergic impairment, and apoptosis in D-galactose-induced aging rat brain.Scientific reports · 2021Article
- Antioxidant, Anti-Aging and Organ Protective Effects of Total Saponins fromDrug design, development and therapy · 2021Article
- Ginsenoside Rg1 protects against Sca-1Experimental and therapeutic medicine · 2020Article
- Anti-Ageing Effect ofInternational journal of molecular sciences · 2020Article
- Rhizoma Paridis total saponins alleviate H2O2‑induced oxidative stress injury by upregulating the Nrf2 pathway.Molecular medicine reports · 2020Article
- Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution.Oxidative medicine and cellular longevity · 2020Review
- Article
- Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling.Cytotechnology · 2018Article
- Paeonol attenuates aging MRC-5 cells and inhibits epithelial-mesenchymal transition of premalignant HaCaT cells induced by aging MRC-5 cell-conditioned medium.Molecular and cellular biochemistry · 2018Article
- Flavonoid-Rich Ethanol Extract from the Leaves ofOxidative medicine and cellular longevity · 2018Article
- Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in MiceOxidative medicine and cellular longevity · 2018Article
- FoxO3a plays a key role in the protective effects of pomegranate peel extract against amikacin-induced ototoxicity.International journal of molecular medicine · 2017Article
- Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin.PloS one · 2017Article
- Effects of rhein lysinate on D-galactose-induced aging mice.Experimental and therapeutic medicine · 2016Article
- Total saponins from Aralia taibaiensis protect against myocardial ischemia/reperfusion injury through AMPK pathway.International journal of molecular medicine · 2015Article
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9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) are closely related to the aging process. In our previous studies, we found that the saponins from Aralia taibaiensis have potent antioxidant activity, suggesting the potential protective activity on the aging. However, the protective effect of the saponins and the possible underlying molecular mechanism remain unknown. In the present study, we employed a D-galactose-induced aging rat model to investigate the protective effect of the saponins. We found that D-galactose treatment induced obvious aging-related changes such as the decreased thymus and spleen coefficients, the increased advanced glycation end products (AGEs) level, senescence-associated β-galactosidase (SAβ-gal) activity, and malondialdehyde (MDA) level. Further results showed that Forkhead box O3a (FOXO3a), nuclear factor-erythroid 2-related factor 2 (Nrf2), and their targeted antioxidants such as superoxide dismutase 2 (SOD2), catalase (CAT), glutathione reductase (GR), glutathione (GSH), glutamate-cysteine ligase (GCL), and heme oxygenase 1 (HO-1) were all inhibited in the aging rats induced by D-galactose treatment. Saponins supplementation showed effective protection on these changes. These results demonstrate that saponins from Aralia taibaiensis attenuate the D-galactose-induced rat aging. By activating FOXO3a and Nrf2 pathways, saponins increase their downstream multiple antioxidants expression and function, at least in part contributing to the protection on the D-galactose-induced aging in rats.
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