ArticleOxidative medicine and cellular longevity2014
Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Trial
- Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Patients.Mediators of inflammation · 2015Trial
- Protective effects of propofol, ketamine, and their combination against HScientific reports · 2026Article
- Berberine protects against lung injury induced by liver transplantation through upregulating PPARγ and suppressing NF-κB-mediated pyroptosis pathway.Acta cirurgica brasileira · 2025Article
- Protective effect of mussel polysaccharide on cyclophosphamide-induced intestinal oxidative stress injury via Nrf2-Keap1 signaling pathway.Food science & nutrition · 2023Article
- Protective Effects ofInternational journal of molecular sciences · 2022Article
- Effect of cardiac output - guided hemodynamic management on acute lung injury in pediatric living donor liver transplantation.World journal of gastrointestinal surgery · 2022Article
- Propofol inhibits oxidative stress injury through the glycogen synthase kinase 3 beta/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway.Bioengineered · 2022Article
- Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia.Military Medical Research · 2021Article
- Signal Pathways and Markers Involved in Acute Lung Injury Induced by Acute Pancreatitis.Disease markers · 2021Review
- Effects of Connexin 32-Mediated Lung Inflammation Resolution During Liver Ischemia Reperfusion.Digestive diseases and sciences · 2020Article
- Article
- Hypoxia-Inducible Factor-1: A Potential Target to Treat Acute Lung Injury.Oxidative medicine and cellular longevity · 2020Review
- The Role of Heme Oxygenase-1 in Remote Ischemic and Anesthetic Organ Conditioning.Antioxidants (Basel, Switzerland) · 2019Review
- Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.International journal of molecular sciences · 2019Article
- Postoperative remote lung injury and its impact on surgical outcome.BMC anesthesiology · 2019Review
- Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol.Kidney international reports · 2019Review
- Effect of Propofol on the Production of Inflammatory Cytokines by Human Polarized Macrophages.Mediators of inflammation · 2019Article
- Lipoxin A4 Ameliorates Acute Pancreatitis-Associated Acute Lung Injury through the Antioxidative and Anti-Inflammatory Effects of the Nrf2 Pathway.Oxidative medicine and cellular longevity · 2019Article
- Neutrophil Elastase Inhibitors Suppress Oxidative Stress in Lung during Liver Transplantation.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment.
methodAdult male Sprague-Dawley rats were divided into five groups based on the random number table. Lung pathology was observed by optical microscopy. Lung water content was assessed by wet/dry ratio, and PaO2 was detected by blood gas analysis. The contents of H2O2, MDA, and SOD activity were determined by ELISA method, and the expression of HO-1, NQO1, Keap1, and nuclear Nrf2 was assayed by western blotting.
resultsCompared with saline-treated model group, both propofol and N-acetylcysteine pretreatment can reduce the acute lung injury caused by orthotopic autologous liver transplantation (OALT), decrease the lung injury scores, lung water content, and H2O2 and MDA levels, and improve the arterial PaO2 and SOD activity. Furthermore, propofol (but not N-acetylcysteine) pretreatment especially in high dose inhibited the expression of Keap1 and induced translocation of Nrf2 into the nucleus to further upregulate the expression of HO-1 and NQO1 downstream.
conclusionPretreatment with propofol is associated with attenuation of OALT-induced ALI, and the Nrf2 pathway is involved in the antioxidative processes.
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