Evidence map›Paper›PMID 24669208›Full record

ArticleCurrent neuropharmacology2014

Oxidative stress and psychological disorders.

Samina Salim

2 registry-linked trialsAbstract read
In one paragraph

Article in Current neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 241 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04736264 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Malay Glaucoma Eye Study II: Elucidating Navigation, Mobility and Reading Ability to Improve Quality of Life and Progression of Primary Glaucoma

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2020 to 2024Enrolled300ConditionsPrimary Open Angle Glaucoma, Primary Angle Closure GlaucomaArmsVisual rehabilitation module: navigation and mobility, Visual rehabilitation module: exercise, Visual rehabilitation module: reading
NCT05868720 naunknown statusnot on this mapstarted 2023, after this paper: background citation

EFFECT OF RISPERIDONE vs ARIPIPRAZOLE ON OXIDATIVE STRESS IN PATIENTS WITH AUTISM SPECTRUM DISORDER: A RANDOMIZED CONTROLLED TRIAL

TypeinterventionalSponsorAll India Institute of Medical Sciences, BhubaneswarRan2023 to 2025Enrolled42ConditionsThe Goal of This Trial is to to Compare the Effect of Risperidone vs Aripiprazole in Terms of Change in Serum Glutathione LevelArmsRisperidone, Aripiprazole
3 · Its place in the literature

Who cites it

241 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Anxiety disorders: a cross-sectional study of clinical and biological associations.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  10. Protective Effects ofPharmaceuticals (Basel, Switzerland) · 2026
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  12. Peripheral S-(PGJBMC psychiatry · 2026
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181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Samina SalimDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Texas, USA.

Funding

Oxidative Stress: A Recipe for Anxiety and Cognitive ImpairmentR15MH093918 · NIMH · UNIVERSITY OF HOUSTON · PI SALIM, SAMINA · 2012 to 2015
$895k
NIMH NIH HHS R15 MH093918
6 · The paper itself

Abstract

Oxidative stress is an imbalance between cellular production of reactive oxygen species and the counteracting antioxidant mechanisms. The brain with its high oxygen consumption and a lipid-rich environment is considered highly susceptible to oxidative stress or redox imbalances. Therefore, the fact that oxidative stress is implicated in several mental disorders including depression, anxiety disorders, schizophrenia and bipolar disorder, is not surprising. Although several elegant studies have established a link between oxidative stress and psychiatric disorders, the causal relationship between oxidative stress and psychiatric diseases is not fully determined. Another critical aspect that needs much attention and effort is our understanding of the association between cellular oxidative stress and emotional stress. This review examines some of the recent discoveries that link oxidative status with anxiety, depression, schizophrenia and bipolar disorder. A discussion of published results and questions that currently exist in the field regarding a causal relationship between oxidative and emotional stress is also provided.

Indexed as

anxietydepression.oxidative stressPsychological stress

Identifiers

PMID24669208
PMCPMC3964745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.