ReviewInfection and drug resistance2014
Community-acquired Clostridium difficile infection: an increasing public health threat.
Review in Infection and drug resistance, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03200093 (Secondary Prophylaxis With Oral Vancomycin for Clostridium Difficile Recurrence), which is not on this map. Cited by 112 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Secondary Prophylaxis With Oral Vancomycin for Clostridium Difficile Recurrence: A Randomized Control Study
Who cites it
112 citing papers in PubMed, 1 synthesis or guideline pooled it, 213 citations in OpenAlex.
- The economic impact of Clostridium difficile infection: a systematic review.The American journal of gastroenterology · 2015Pooled it
- A Phase 2 Study Evaluating the Safety, Tolerability, and Immunogenicity of Two 3-Dose Regimens of a Clostridium difficile Vaccine in Healthy US Adults Aged 65 to 85 Years.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- One Health genomic insights into environmental and animal reservoirs of community-associatedApplied and environmental microbiology · 2026Article
- Silent Megacolon: FulminantACG case reports journal · 2026Article
- Epidemiology ofAntibiotics (Basel, Switzerland) · 2026Article
- Sub-inhibitory concentrations of metronidazole alter the proteomic profile and biological effects of extracellular vesicles from Clostridioides difficile.BMC microbiology · 2026Article
- Clostridioides difficile-Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages.Journal of extracellular vesicles · 2026Article
- Addressing Unmet Needs inCurrent medicinal chemistry · 2026Review
- Smoking andInfection and drug resistance · 2026Article
- Potential pathogens and antimicrobial resistance genes in household environments: a study of soil floors and cow dung in rural Bangladesh.Applied and environmental microbiology · 2025Article
- Community-AcquiredInternational journal of molecular sciences · 2025Review
- Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with ConcurrentBiomedicines · 2025Article
- Can Gut Microbiota Analysis RevealMicroorganisms · 2024Article
- Review
- Article
- Review
- RethinkingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Ribotypes and New Virulent Strains Across Europe.Advances in experimental medicine and biology · 2024Review
- Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023Review
- Update on Commonly Used Molecular Typing Methods forMicroorganisms · 2023Review
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been a startling shift in the epidemiology of Clostridium difficile infection over the last decade worldwide, and it is now increasingly recognized as a cause of diarrhea in the community. Classically considered a hospital-acquired infection, it has now emerged in populations previously considered to be low-risk and lacking the traditional risk factors for C. difficile infection, such as increased age, hospitalization, and antibiotic exposure. Recent studies have demonstrated great genetic diversity for C. difficile, pointing toward diverse sources and a fluid genome. Environmental sources like food, water, and animals may play an important role in these infections, apart from the role symptomatic patients and asymptomatic carriers play in spore dispersal. Prospective strain typing using highly discriminatory techniques is a possible way to explore the suspected diverse sources of C. difficile infection in the community. Patients with community-acquired C. difficile infection do not necessarily have a good outcome and clinicians should be aware of factors that predict worse outcomes in order to prevent them. This article summarizes the emerging epidemiology, risk factors, and outcomes for community-acquired C. difficile infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.