Evidence map›Paper›PMID 24668768›Full record

ReviewMuscle & nerve2014

Respiratory assessment in centronuclear myopathies.

Barbara K Smith, Melissa Goddard, Martin K Childers

Open access · greenAbstract readReview
In one paragraph

Review in Muscle & nerve, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Evaluation of respiratory status in patients with myopathy.Journal of education and health promotion · 2026
    Article
  2. Article
  3. Gene therapy in monogenic congenital myopathies.Methods (San Diego, Calif.) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Barbara K SmithDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Melissa Goddard
Martin K Childers
University of Florida · USUniversity of Washington · USWake Forest University · US

Funding

Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Gene therapy in canine myotubular myopathy for clinical translationR01HL115001 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHILDERS, MARTIN K · 2013 to 2017
$3.9M
Establishing endpoints in canine myotubular myopathy for clinical translationR21AR064503 · NIAMS · UNIVERSITY OF WASHINGTON · PI CHILDERS, MARTIN K · 2012 to 2013
$389k
NHLBI NIH HHS 1R01HL115001NHLBI NIH HHS R01 HL115001NIAMS NIH HHS 1R21AR064503NIAMS NIH HHS R21 AR064503NICHD NIH HHS K12 HD055929NICHD NIH HHS K12HD055929
6 · The paper itself

Abstract

The centronuclear myopathies (CNMs) are a group of inherited neuromuscular disorders classified as congenital myopathies. While several causative genes have been identified, some patients do not harbor any of the currently known mutations. These diverse disorders have common histological features, which include a high proportion of centrally nucleated muscle fibers, and clinical attributes of muscle weakness and respiratory insufficiency. Respiratory problems in CNMs may manifest initially during sleep, but daytime symptoms, ineffective airway clearance, and hypoventilation predominate as more severe respiratory muscle dysfunction evolves. Respiratory muscle capacity can be evaluated using a variety of clinical tests selected with consideration for the age and baseline motor function of the patient. Similar clinical tests of respiratory function can also be incorporated into preclinical CNM canine models to offer insight for clinical trials. Because respiratory problems account for significant morbidity in patients, routine assessments of respiratory muscle function are discussed.

Indexed as

AnimalsDisease Models, AnimalHumansMuscle, SkeletalMuscle WeaknessMyopathies, Structural, CongenitalRespiration, ArtificialRespiration DisordersRespiratory Function Testscaninegeneticsmuscle diseasemyopathyrespiratory assessment

Identifiers

PMID24668768
PMCPMC4140950
OpenAlexW2110031485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.