ArticleCognitive, affective & behavioral neuroscience2014
Dissociable effects of basolateral amygdala lesions on decision making biases in rats when loss or gain is emphasized.
Article in Cognitive, affective & behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Decision making in Parkinson's disease: An analysis of the studies using the Iowa Gambling Task.The European journal of neuroscience · 2021Pooled it
- Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine.bioRxiv : the preprint server for biology · 2024Article
- GABANeuropharmacology · 2022Article
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- Translating concepts of risk and loss in rodent models of gambling and the limitations for clinical applications.Current opinion in behavioral sciences · 2020Article
- Exploring preferences for variable delays over fixed delays to high-value food rewards as a model of food-seeking behaviours in humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Review: brain neurobiology of gambling disorder based on rodent models.Neuropsychiatric disease and treatment · 2019Review
- Understanding Addiction Using Animal Models.Frontiers in behavioral neuroscience · 2019Article
- Optogenetic Inhibition Reveals Distinct Roles for Basolateral Amygdala Activity at Discrete Time Points during Risky Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder.Journal of psychiatry & neuroscience : JPN · 2017Article
- Reinforcement learning models of risky choice and the promotion of risk-taking by losses disguised as wins in rats.Journal of experimental psychology. Animal learning and cognition · 2017Article
- Neural responses to negative outcomes predict success in community-based substance use treatment.Addiction (Abingdon, England) · 2017Article
- Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Prefrontal Cortical Inactivations Decrease Willingness to Expend Cognitive Effort on a Rodent Cost/Benefit Decision-Making Task.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Differential Involvement of the Agranular vs Granular Insular Cortex in the Acquisition and Performance of Choice Behavior in a Rodent Gambling Task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- The basolateral amygdala in reward learning and addiction.Neuroscience and biobehavioral reviews · 2015Review
- Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models.Molecular psychiatry · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Individuals switch from risk seeking to risk aversion when mathematically identical options are described in terms of loss versus gains, as exemplified in the reflection and framing effects. Determining the neurobiology underlying such cognitive biases could inform our understanding of decision making in health and disease. Although reports vary, data using human subjects have implicated the amygdala in such biases. Animal models enable more detailed investigation of neurobiological mechanisms. We therefore tested whether basolateral amygdala (BLA) lesions would affect risk preference for gains or losses in rats. Choices in both paradigms were always between options of equal expected value-a guaranteed outcome, or the 50:50 chance of double or nothing. In the loss-chasing task, most rats exhibited strong risk seeking preferences, gambling at the risk of incurring double the penalty, regardless of the size of the guaranteed loss. In the betting task, the majority of animals were equivocal in their choice, irrespective of bet size; however, a wager-sensitive subgroup progressively shifted away from the uncertain option as the bet size increased, which is reminiscent of risk aversion. BLA lesions increased preference for the smaller guaranteed loss in the loss-chasing task, without affecting choice on the betting task, which is indicative of reduced risk seeking for losses, but intact risk aversion for gains. These data support the hypothesis that the amygdala plays a more prominent role in choice biases related to losses. Given the importance of the amygdala in representing negative affect, the aversive emotional reaction to loss, rather than aberrant estimations of probability or loss magnitude, may underlie risk seeking for losses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.