SynthesisEuropean cells & materials2014
A systematic review of animal models for Staphylococcus aureus osteomyelitis.
Synthesis in European cells & materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Comparing the efficacy of different antibiotic regimens on osteomyelitis: A network meta-analysis of animal studies.Frontiers in medicine · 2022Pooled it
- Biomaterials approaches to treating implant-associated osteomyelitis.Biomaterials · 2016Pooled it
- A novel mouse calvarial defect model of osteomyelitis induced by Staphylococcus aureus (ATCC 6538).Laboratory animal research · 2026Article
- Modulating Micrococcal Nuclease-Triggered Antibiotic Releases for One-Stage Revisions ofACS infectious diseases · 2026Article
- Adaptive hydrogel platforms for infected bone defect repair: microenvironmental responsiveness, osteoimmunomodulation, and regenerative remodeling.Frontiers in bioengineering and biotechnology · 2026Review
- Feasibility of a rat femoral-defect model for immediate perioperative and delayed post-implantation implant-associated bone infections.Journal of bone and joint infection · 2026Article
- Osteomyelitis related lameness across animal species: pathophysiology, etiology, epidemiology and experimental model approaches.Frontiers in veterinary science · 2026Review
- Purified Native Collagen Extracellular Matrix Plus Polyhexamethylene Biguanide Functions as a Barrier to Protect Complex Wounds in an In Vivo Model.International journal of molecular sciences · 2025Article
- Animal Models of Orthopedic Implant-Associated Infections and Revisions.ACS biomaterials science & engineering · 2025Review
- Development of a small animal bone-anchored limb replacement model for infection interventions.OTA international : the open access journal of orthopaedic trauma · 2025Review
- Evaluation of effects of vancomycin/polycaprolactone nanocomposite in comparison with curcumin/polycaprolactone on the healing of experimental osteomyelitis in rabbit tibia.Veterinary research forum : an international quarterly journal · 2025Article
- The Application of Rat Models inPathogens (Basel, Switzerland) · 2024Review
- Article
- Anti-Staphylococcal Activity ofAntibiotics (Basel, Switzerland) · 2023Article
- Size-dependent gold nanoparticles induce macrophage M2 polarization and promote intracellular clearance ofMaterials today. Bio · 2023Article
- Positron Emission Tomography-Computed Tomography and Magnetic Resonance Imaging Assessments in a Mouse Model of Implant-Related Bone and Joint Staphylococcus aureus Infection.Microbiology spectrum · 2023Article
- Local Antibiotic Delivery Ceramic Bone Substitutes for the Treatment of Infected Bone Cavities and Bone Regeneration: A Systematic Review on What We Have Learned from Animal Models.Materials (Basel, Switzerland) · 2023Review
- Murine models of orthopedic infection featuringJournal of bone and joint infection · 2023Article
- Antimicrobial Biomaterials for the Healing of Infected Bone Tissue: A Systematic Review of Microtomographic Data on Experimental Animal Models.Journal of functional biomaterials · 2022Review
- The Medium Composition ImpactsInternational journal of molecular sciences · 2022Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus (S. aureus) osteomyelitis is a significant complication for orthopaedic patients undergoing surgery, particularly with fracture fixation and arthroplasty. Given the difficulty in studying S. aureus infections in human subjects, animal models serve an integral role in exploring the pathogenesis of osteomyelitis, and aid in determining the efficacy of prophylactic and therapeutic treatments. Animal models should mimic the clinical scenarios seen in patients as closely as possible to permit the experimental results to be translated to the corresponding clinical care. To help understand existing animal models of S. aureus, we conducted a systematic search of PubMed and Ovid MEDLINE to identify in vivo animal experiments that have investigated the management of S. aureus osteomyelitis in the context of fractures and metallic implants. In this review, experimental studies are categorised by animal species and are further classified by the setting of the infection. Study methods are summarised and the relevant advantages and disadvantages of each species and model are discussed. While no ideal animal model exists, the understanding of a model's strengths and limitations should assist clinicians and researchers to appropriately select an animal model to translate the conclusions to the clinical setting.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.