ArticleWorld journal of pediatrics : WJP2014
Thyroid peroxidase antibody positivity and triiodothyronine levels are associated with pediatric Graves' ophthalmopathy.
Article in World journal of pediatrics : WJP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Thyroid eye disease in paediatric Graves' disease: a case series from the Gulf region with comparison to adults.International ophthalmology · 2026Article
- Ocular manifestations and immunological profiles of thyroid eye disease with lacrimal gland enlargement.Frontiers in endocrinology · 2026Article
- The clinical characteristics and treatment response of myasthenia gravis with positive thyroid peroxidase antibody or thyroid globulin antibody.Journal of translational autoimmunity · 2025Article
- Pediatric graves' orbitopathy: a case series of 136 Chinese patients.International ophthalmology · 2025Article
- Correlation between choroidal vascularity and retrobulbar ocular blood flow changes and thyroid-associated ophthalmopathy activity: a cross-sectional study.BMC ophthalmology · 2024Article
- Clinical significance of thyroglobulin antibodies and thyroid peroxidase antibodies in Graves' disease: a cross-sectional study.Hormones (Athens, Greece) · 2023Article
- The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves' Disease in Basrah.Cureus · 2023Article
- Thicknesses of the retinal layers in patients with Graves' disease with or without orbitopathy.International ophthalmology · 2022Article
- The risk factors for Graves' ophthalmopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Review
- Comparison of the ocular surface microbiota between thyroid-associated ophthalmopathy patients and healthy subjects.Frontiers in cellular and infection microbiology · 2022Article
- Risk factors for Graves' Orbitopathy in surgical patients-Results of a 10-year retrospective study with review of the literature.Endocrinology, diabetes & metabolism · 2021Review
- Thyroid-Associated Orbitopathy and Biomarkers: Where We Are and What We Can Hope for the Future.Disease markers · 2018Review
- Gender-dependent and age-of-onset-specific association of the rs11675434 single-nucleotide polymorphism near TPO with susceptibility to Graves' ophthalmopathy.Journal of human genetics · 2017Article
- Predictive Factors of Development of Graves' Ophthalmopathy for Patients with Juvenile Graves' Disease.International journal of endocrinology · 2016Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGraves' ophthalmopathy (GO) occurs commonly in children with Graves' disease (GD). However, there are limited studies on the clinical manifestations and thyroid autoantibodies in pediatric GO. The aim of this study was to investigate the prevalence and risk factors of GO in childhood GD.
methodsClinical and biochemical data from children and adolescents with GD were retrospectively reviewed. Eighty patients under 19 years of age were included in the present study. We compared the clinical and biochemical differences between patients with and without GO.
resultsThirty-nine percent of the patients had GO, and 81% of the GO patients were females. Of these, two patients showed unilateral GO. Triiodothyronine (T3) levels were higher in GO patients than in those without GO. Anti-thyroglobulin antibody and thyroid stimulating hormone receptor antibody titers were not significantly different between the two groups. Anti-thyroid peroxidase antibody (TPO Ab) positivity was 68% in the patients with GO and only 47% in the patients without GO. In multivariate regression analysis, high T3 levels and TPO Ab positivity were related to the presence of GO.
conclusionIn children and adolescents with GD, TPO Ab positivity and high T3 levels could act as predictive factors for the presence of GO.
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