ArticleNeurochemical research2014
The role of the δ GABA(A) receptor in ovarian cycle-linked changes in hippocampus-dependent learning and memory.
Article in Neurochemical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons.Frontiers in cellular neuroscience · 2023Article
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Sex differences in contextual fear learning and generalization: a behavioral and computational analysis of hippocampal functioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Assessing the importance of sex in a hippocampus-dependent behavioral test battery in C57BL/6NTac mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Impact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake.Neurobiology of stress · 2021Article
- Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.Cell reports · 2021Article
- Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.Brain structure & function · 2021Article
- Estrous Cycle Monitoring in Mice with Rapid Data Visualization and Analysis.Bio-protocol · 2019Article
- General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.Neuropharmacology · 2019Article
- An Emerging Circuit Pharmacology of GABATrends in pharmacological sciences · 2018Review
- The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.Cell · 2018Article
- Across sex and age: Learning and memory and patterns of avian hippocampal gene expression.Behavioral neuroscience · 2017Article
- Activation of extrasynaptic δ-GABAHormones and behavior · 2017Article
- Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory.Hippocampus · 2016Article
- Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats.Scientific reports · 2016Article
- Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse.Brain research · 2015Article
- C/EBPβ Isoforms Expression in the Rat Brain during the Estrous Cycle.International journal of endocrinology · 2015Article
- Ovarian cycle-linked plasticity of δ-GABAA receptor subunits in hippocampal interneurons affects γ oscillations in vivo.Frontiers in cellular neuroscience · 2014Article
- Sex and estrous cycle effects on stress-enhanced fear learning in Long-Evans rats.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of the estrous cycle. Previous work in our lab found that female δ-GABAAR KO mice showed enhanced hippocampus-dependent trace but normal hippocampus-independent delay fear conditioning. Wild-type females in this study showed a wide range of freezing levels, whereas δ-GABAAR KO mice expressed only high levels of fear. We hypothesized that the variability in the wild-type mice may have been due to estrous cycle-mediated changes in the expression of the δ-GABAAR, with low levels of freezing in mice that were in the diestrous phase when dentate gyrus tonic inhibition is high. In the present study we tested this hypothesis by utilizing contextual, delay, and trace fear conditioning protocols in mice that were trained and tested in either the diestrous or estrous phases. Consistent with our hypothesis, we found a significant impairment of hippocampus-dependent learning and memory during diestrus relative to estrus in wild-type mice and this impairment was absent in δ-GABAAR mice. These findings argue that the δ-GABAAR plays an important role in estrous cycle-mediated fluctuations in hippocampus-dependent learning and memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.