Evidence map›Paper›PMID 24667908›Full record

Trial reportBlood pressure monitoring2014

An analysis of 24-h ambulatory blood pressure monitoring data using orthonormal polynomials in the linear mixed model.

Lloyd J Edwards, Sean L Simpson

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Blood pressure monitoring, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Statistical Brain Network Analysis.Annual review of statistics and its application · 2024
    Article
  2. A mixed-modeling framework for whole-brain dynamic network analysis.Network neuroscience (Cambridge, Mass.) · 2022
    Article
  3. Article
  4. Mixed Modeling Frameworks for Analyzing Whole-Brain Network Data.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lloyd J EdwardsaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill bDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Sean L Simpson

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
UNC Clinical and Translational Science AwardUL1TR000083 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2012 to 2013
$11.6M
Statistical Methods for Whole-Brain Connectivety NetworksK25EB012236 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SIMPSON, SEAN L · 2012 to 2016
$796k
NCATS NIH HHS UL1 TR000083NCATS NIH HHS UL1TR000083NCATS NIH HHS UL1 TR001111NIBIB NIH HHS K25 EB012236NIBIB NIH HHS K25 EB012236-01A1
6 · The paper itself

Abstract

backgroundThe use of 24-h ambulatory blood pressure monitoring (ABPM) in clinical practice and observational epidemiological studies has grown considerably in the past 25 years. ABPM is a very effective technique for assessing biological, environmental, and drug effects on blood pressure.

objectivesIn order to enhance the effectiveness of ABPM for clinical and observational research studies using analytical and graphical results, developing alternative data analysis approaches using modern statistical techniques are important.

methodsThe linear mixed model for the analysis of longitudinal data is particularly well suited for the estimation of, inference about, and interpretation of both population (mean) and subject-specific trajectories for ABPM data. We propose using a linear mixed model with orthonormal polynomials across time in both the fixed and random effects to analyze ABPM data.

resultsWe demonstrate the proposed analysis technique using data from the Dietary Approaches to Stop Hypertension (DASH) study, a multicenter, randomized, parallel arm feeding study that tested the effects of dietary patterns on blood pressure.

conclusionThe linear mixed model is relatively easy to implement (given the complexity of the technique) using available software, allows for straightforward testing of multiple hypotheses, and the results can be presented to research clinicians using both graphical and tabular displays. Using orthonormal polynomials provides the ability to model the nonlinear trajectories of each subject with the same complexity as the mean model (fixed effects).

Indexed as

Blood Pressure Monitoring, AmbulatoryDatabases, FactualHypertensionModels, CardiovascularFemaleHumansMale

Identifiers

PMID24667908
PMCPMC4058995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.