Evidence map›Paper›PMID 24667894›Full record

Trial reportPloS one2014

Gender-specific impacts of apnea, age, and BMI on parasympathetic nerve dysfunction during sleep in patients with obstructive sleep apnea.

Kazuhiro Yamaguchi, Yuji Inoue, Noboru Ohki, Natsumi Satoya, Fukumi Inoue, Yoshiko Maeda, Haruki Sekiguchi, Mayumi Suzuki, Takao Tsuji, Kazutetsu Aoshiba and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kazuhiro YamaguchiComprehensive Medical Center of Sleep Disorders, Aoyama Hospital, Tokyo Women's Medical University, Minato-ku, Tokyo, Japan.
Yuji InoueComprehensive Medical Center of Sleep Disorders, Aoyama Hospital, Tokyo Women's Medical University, Minato-ku, Tokyo, Japan.
Noboru OhkiNoruPro Light Systems Incorporation, Kokubunji-shi, Tokyo, Japan.
Natsumi SatoyaComprehensive Medical Center of Sleep Disorders, Aoyama Hospital, Tokyo Women's Medical University, Minato-ku, Tokyo, Japan.
Fukumi InoueComprehensive Medical Center of Sleep Disorders, Aoyama Hospital, Tokyo Women's Medical University, Minato-ku, Tokyo, Japan.
Yoshiko MaedaDepartment of Urology, Aoyama Hospital, Tokyo Women's Medical University, Minato-ku, Tokyo, Japan.
Haruki SekiguchiDepartment of Cardiology, Aoyama Hospital, Tokyo Women's Medical University, Minato-ku, Tokyo, Japan.
Mayumi SuzukiComprehensive Medical Center of Sleep Disorders, Aoyama Hospital, Tokyo Women's Medical University, Minato-ku, Tokyo, Japan.
Takao TsujiDepartment of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki, Japan.
Kazutetsu AoshibaDepartment of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki, Japan.
Atsushi NagaiThe First Department of Medicine, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
Aoyama Hospital Tokyo Women’s Medical University · JPTokyo Medical University Ibaraki Medical Center · JPTokyo Women's Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gender-specific influences of various confounding factors, including apnea, age, BMI, and cigarette consumption, on the function of the parasympathetic nerve system (PNS) during sleep in OSA patients has never been investigated.

methodsOne hundred ninety-seven males and 63 females with OSA were subjected to full PSG examinations including assessment of R-R intervals (RRIs) during an overnight ECG. The PNS-derived modulatory effect on the RRIs and the variability of this effect were quantified during REM and NREM using instantaneous time-frequency analysis with complex demodulation. The spectral domain with the maximum instantaneous amplitude in the high-frequency band between 0.15 and 0.4 Hz was defined as the main HF peak and used as a surrogate marker of PNS discharge. Based on density-spectrum-array maps of the main HF peaks (HF-DSA map), shifts in the central frequency of the main HF peak over time were continuously observed. When the main HF peaks on the HF-DSA maps maintained the same central frequency for more than 20 sec or 5 min, the PNS functions were considered to be "stable" or "very stable", respectively.

resultsApneas enhanced PNS-derived cardiac-modulation during REM in males, but more importantly, they made PNS-function unstable during both REM and NREM in males and during NREM in females. Aging blunted the PNS-derived cardiac-modulation during both REM and NREM regardless of gender, but aging had no impact on the stability of PNS-function. BMI blunted PNS-eliciting cardiac-modulation during REM in males and during NREM in both males and females. BMI made the PNS unstable during REM in females. Neither height nor cigarette consumption influenced any PNS-related parameter.

conclusionsThe PNS-derived cardiac-modulation was generally inhibited by aging and obesity, in which the effect of obesity was gender-specific. The PNS instability at nighttime was mainly induced by apneas but by obesity particularly during REM in females.

Indexed as

Sex CharacteristicsSleep, REMAdultAgedAged, 80 and overAge FactorsAutonomic Nervous System DiseasesFemaleHumansMaleMiddle AgedSex FactorsSleep Apnea, ObstructiveSmoking

Identifiers

PMID24667894
PMCPMC3965452
OpenAlexW2036605808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.