ArticlePloS one2014
Increased risk of benign prostate hyperplasia in sleep apnea patients: a nationwide population-based study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Observational
- Relationship between REI and PSA in patients with obstructive sleep apnea: a prospective case-control study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Association between sleep quality and benign prostate hyperplasia among middle-aged and older men in India.BMC public health · 2023Article
- The association between cataract and sleep apnea: a nationwide population-based cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Increased risk of major depressive disorder in sleep apnea patients in Taiwan.Scientific reports · 2021Article
- The Association between Temporomandibular Disorder and Sleep Apnea-A Nationwide Population-Based Cohort Study.International journal of environmental research and public health · 2020Article
- Article
- CHADS₂, CHA₂DS₂ASc, and New ABCD Scores Predict the Risk of Peripheral Arterial Disease in Patients with Sleep Apnea.Journal of clinical medicine · 2019Article
- Nonadherence to CPAP Associated With Increased 30-Day Hospital Readmissions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Article
- Obstructive sleep apnea and urological comorbidities in males: a population-based study.Sleep & breathing = Schlaf & Atmung · 2016Article
- Laparoscopic Sleeve Gastrectomy Improves Excessive Daytime Sleepiness and Sleep Quality 6 Months Following Surgery: A Prospective Cohort Study.Advances in therapy · 2016Article
- Erectile Dysfunction in Patients with Sleep Apnea--A Nationwide Population-Based Study.PloS one · 2015Article
- Comparing the Strength of Associations Between Male Genital Problems and Mental Illnesses and Sleep Disorders.American journal of men's healthArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population.
methodsThe study population was identified from Taiwan's National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥ 30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients.
resultsDuring the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28-4.29, P<.01). We further divided the SA patients into 4 age groups. After adjusting for potential confounding factors, the highest adjusted HR for BPH in the SA patients compared with the control patients was 5.59 (95% CI = 2.19-14.31, P<.001) in the patients aged between 51 and 65 years.
conclusionOur study results indicate that patients with SA are associated with increased longitudinal risk of BPH development, and that the effects of SA on BPH development are age-dependent.
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