Evidence map›Paper›PMID 24667786›Full record

ArticleEuropean journal of human genetics : EJHG2015

The phylogenetic and geographic structure of Y-chromosome haplogroup R1a.

Peter A Underhill, G David Poznik, Siiri Rootsi, Mari Järve, Alice A Lin, Jianbin Wang, Ben Passarelli, Jad Kanbar, Natalie M Myres, Roy J King and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of human genetics : EJHG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Trial
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  12. Genetic history of Scythia.Science advances · 2025
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  18. Article
  19. Review
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Peter A UnderhillDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
G David PoznikProgram in Biomedical Informatics and Department of Statistics, Stanford University, Stanford, CA, USA.
Siiri RootsiEstonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia.
Mari JärveEstonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia.
Alice A LinDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Jianbin WangDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Ben PassarelliDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Jad KanbarDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Natalie M MyresAncestry DNA, Provo, UT, USA.
Roy J KingDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Julie Di CristofaroUMR 7268 ADES, Aix-Marseille Université/EFS/CNRS, Marseille, France.
Hovhannes Sahakyan1] Estonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia [2] Laboratory of Ethnogenomics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.
Doron M Behar1] Estonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia [2] Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa, Israel.
Alena KushniarevichEstonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia.
Jelena Sarac1] Estonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia [2] Institute for Anthropological Research, Zagreb, Croatia.
Tena Saric1] Estonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia [2] Institute for Anthropological Research, Zagreb, Croatia.
Pavao Rudan1] Institute for Anthropological Research, Zagreb, Croatia [2] Croatian Academy of Sciences and Arts, Zagreb, Croatia.
Ajai Kumar PathakEstonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia.
Gyaneshwer ChaubeyEstonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia.
Viola GrugniDipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani', Università di Pavia, Pavia, Italy.
Ornella Semino1] Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani', Università di Pavia, Pavia, Italy [2] Centro Interdipartimentale 'Studi di Genere', Università di Pavia, Pavia, Italy.
Levon YepiskoposyanLaboratory of Ethnogenomics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.
Ardeshir BahmanimehrDepartment of Medical Genetic, Shiraz University of Medical Sciences, Shiraz, Iran.
Shirin FarjadianDepartment of Immunology, Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Oleg BalanovskyResearch Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia.
Elza K Khusnutdinova1] Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia [2] Department of Biology, Bashkir State University, Ufa, Russia.
Rene J HerreraDepartment of Human and Molecular Genetics, College of Medicine, Florida International University, Miami, FL, USA.
Jacques ChiaroniUMR 7268 ADES, Aix-Marseille Université/EFS/CNRS, Marseille, France.
Carlos D BustamanteDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Stephen R Quake1] Department of Bioengineering, Stanford University, Stanford, CA, USA [2] Department of Applied Physics, Stanford University, Stanford, CA, USA [3] Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Toomas Kivisild1] Estonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia [2] Division of Biological Anthropology, University of Cambridge, Cambridge, UK.
Richard Villems1] Estonian Biocentre and the Department of Evolutionary Biology, University of Tartu, Tartu, Estonia [2] Estonian Academy of Sciences, Tallinn, Estonia.

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

R1a-M420 is one of the most widely spread Y-chromosome haplogroups; however, its substructure within Europe and Asia has remained poorly characterized. Using a panel of 16 244 male subjects from 126 populations sampled across Eurasia, we identified 2923 R1a-M420 Y-chromosomes and analyzed them to a highly granular phylogeographic resolution. Whole Y-chromosome sequence analysis of eight R1a and five R1b individuals suggests a divergence time of ∼25,000 (95% CI: 21,300-29,000) years ago and a coalescence time within R1a-M417 of ∼5800 (95% CI: 4800-6800) years. The spatial frequency distributions of R1a sub-haplogroups conclusively indicate two major groups, one found primarily in Europe and the other confined to Central and South Asia. Beyond the major European versus Asian dichotomy, we describe several younger sub-haplogroups. Based on spatial distributions and diversity patterns within the R1a-M420 clade, particularly rare basal branches detected primarily within Iran and eastern Turkey, we conclude that the initial episodes of haplogroup R1a diversification likely occurred in the vicinity of present-day Iran.

Indexed as

AllelesChromosomes, Human, YHaplotypesPhylogenyPhylogeographyAsiaEthnicityEuropeEvolution, MolecularGene FrequencyGenetic LinkageHumansMaleMicrosatellite RepeatsPolymorphism, Single NucleotideSpatial Analysis

Identifiers

PMID24667786
PMCPMC4266736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.