ArticleNature neuroscience2014
Reversed theta sequences of hippocampal cell assemblies during backward travel.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- Naturalistic behavior and self-generated neural activity predictive of self-correction.bioRxiv : the preprint server for biology · 2026Article
- Review
- Theta-nested gamma oscillations balance prediction and vigilance in spatial navigation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Hippocampal phase precession may be generated by chimera dynamics.Frontiers in neural circuits · 2025Article
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.PLoS biology · 2025Article
- Mental Time Travel: A Retrospective.Hippocampus · 2025Review
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.bioRxiv : the preprint server for biology · 2024Article
- A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences.eLife · 2023Article
- Beyond rhythm - A framework for understanding the frequency spectrum of neural activity.bioRxiv : the preprint server for biology · 2023Article
- Learning to predict future locations with internally generated theta sequences.PLoS computational biology · 2023Article
- Hippocampal 4-Hz oscillations emerge during stationary running in a wheel and are resistant to medial septum inactivation.PloS one · 2023Article
- Beyond rhythm - a framework for understanding the frequency spectrum of neural activity.Frontiers in systems neuroscience · 2023Article
- Activity-dependent Organization of Topographic Neural Circuits.Neuroscience · 2023Review
- Article
- Multiple-Timescale Representations of Space: Linking Memory to Navigation.Annual review of neuroscience · 2022Review
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Ripple band phase precession of place cell firing during replay.Current biology : CB · 2022Article
- Article
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Authors and funding
5 authors.
Funding
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Abstract
Hippocampal cell assemblies coding for past, present and future events form theta-timescale (~100 ms) sequences that represent spatio-temporal episodes. However, the underlying mechanisms remain largely unknown. We recorded hippocampal and entorhinal cortical activity as rats experienced backward travel on a model train. Although the firing fields of place cells remained stable, the order in which they were activated in the theta sequence was reversed during backward travel. Thus, hippocampal cell assemblies coordinated their relative timing to correctly predict the sequential traversal of place fields in reverse order. At the single-cell level, theta phase represented distance traveled through the field, even though the head of the rat was oriented opposite to travel direction and entorhinal head-direction cells maintained their preferred firing direction. Our results challenge most theoretical models of theta sequence generation in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.