ArticlePloS one2014
Platelet serotonin transporter function predicts default-mode network activity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Prefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study.Translational psychiatry · 2019Trial
- Proteomic Analysis of the Antidepressant Effects of Shen-Zhi-Ling in Depressed Patients: Identification of Proteins Associated with Platelet Activation and Lipid Metabolism.Cellular and molecular neurobiology · 2018Trial
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- Personalized prediction of one-year mental health deterioration using adaptive learning algorithms: a multicenter breast cancer prospective study.Scientific reports · 2023Article
- Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder.Schizophrenia bulletin · 2020Article
- Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders.Molecular psychiatry · 2020Review
- Relations between cortical thickness, serotonin 1A receptor binding, and structural connectivity: A multimodal imaging study.Human brain mapping · 2018Article
- Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder.Neuropsychiatric disease and treatment · 2016Article
- 5-HT2A Gene Variants Moderate the Association between PTSD and Reduced Default Mode Network Connectivity.Frontiers in neuroscience · 2016Article
- Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults.Brain structure & function · 2016Article
- fMRI measurements of amygdala activation are confounded by stimulus correlated signal fluctuation in nearby veins draining distant brain regions.Scientific reports · 2015Article
- Decreased mean platelet volume in panic disorder.Neuropsychiatric disease and treatment · 2014Article
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Authors and funding
25 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. A blood-brain relationship between platelet and synaptosomal 5-HT reuptake has been suggested, but it is unknown today, if platelet 5-HT uptake can predict neural activation of human brain networks that are known to be under serotonergic influence.
methodsA functional magnetic resonance study was performed in 48 healthy subjects and maximal 5-HT uptake velocity (Vmax) was assessed in blood platelets. We used a mixed-effects multilevel analysis technique (MEMA) to test for linear relationships between whole-brain, blood-oxygen-level dependent (BOLD) activity and platelet Vmax.
resultsThe present study demonstrates that increases in platelet Vmax significantly predict default-mode network (DMN) suppression in healthy subjects independent of genetic variation within SLC6A4. Furthermore, functional connectivity analyses indicate that platelet Vmax is related to global DMN activation and not intrinsic DMN connectivity.
conclusionThis study provides evidence that platelet Vmax predicts global DMN activation changes in healthy subjects. Given previous reports on platelet-synaptosomal Vmax coupling, results further suggest an important role of neuronal 5-HT reuptake in DMN regulation.
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