Evidence map›Paper›PMID 24667458›Full record

ArticleDiabetes care2014

Interarm blood pressure difference in people with diabetes: measurement and vascular and mortality implications: a cohort study.

Christopher E Clark, Anna M Steele, Rod S Taylor, Angela C Shore, Obioha C Ukoumunne, John L Campbell

Open access · hybridAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Prevalence of systolic inter-arm differences in blood pressure for different primary care populations: systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016
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  4. Inter-arm blood pressure difference and mortality: a cohort study in an asymptomatic primary care population at elevated cardiovascular risk.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016
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  11. Inter-Arm Blood Pressure Difference an Indicator of Coronary Artery Disease.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Christopher E ClarkPrimary Care Research Group, Institute of Health Services Research, University of Exeter Medical School, Exeter, Devon, U.K. c.e.clark@exeter.ac.uk.
Anna M SteeleNIHR Exeter Clinical Research Facility, Royal Devon and Exeter Hospital and University of Exeter Medical School, Exeter, Devon, U.K.
Rod S TaylorPrimary Care Research Group, Institute of Health Services Research, University of Exeter Medical School, Exeter, Devon, U.K.
Angela C ShoreNIHR Exeter Clinical Research Facility, Royal Devon and Exeter Hospital and University of Exeter Medical School, Exeter, Devon, U.K.
Obioha C UkoumunnePeninsula Collaboration for Leadership in Applied Health Research and Care (PenCLAHRC), University of Exeter Medical School, Exeter, Devon, U.K.
John L CampbellPrimary Care Research Group, Institute of Health Services Research, University of Exeter Medical School, Exeter, Devon, U.K.
University of Exeter · GBRoyal Devon and Exeter Hospital · GBPeninsula College of Medicine and Dentistry · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDifferences in blood pressure between arms are associated with vascular disease and increased mortality; this has not been reported in diabetes. We explored these associations, and assessed reference standard and pragmatic measurement techniques, in people with diabetes and in nondiabetic controls. RESEARCH DESIGN AND

methodsA prospective cohort study in Devon, England, recruited 727 people with type 1 or type 2 diabetes and 285 nondiabetic controls. Simultaneous repeated measurements of bilateral blood pressure were made at recruitment. Data were used to inform a pragmatic measurement strategy. Interarm differences were examined for cross-sectional associations with target organ disease and prospective mortality associations (median follow-up 52 months).

resultsWe found 8.6% of participants with diabetes and 2.9% of controls had systolic interarm differences ≥10 mmHg. Single pairs of blood pressure measurements had high negative predictive values (97-99%) for excluding interarm differences. Systolic interarm differences ≥10 mmHg in diabetes were associated with peripheral arterial disease (odds ratio [OR] 3.4 [95% CI 1.2-9.3]). Differences ≥15 mmHg were associated with diabetic retinopathy (OR 5.7 [1.5-21.6]) and chronic kidney disease (OR 7.0 [1.7-29.8]). Systolic interarm differences were associated prospectively with increased cardiovascular mortality: hazard ratios 3.5 (1.0-13.0) for ≥10 mmHg and 9.0 (2.0-41.0) for ≥15 mmHg.

conclusionsBlood pressure should be measured in both arms during initial assessment in diabetes. Systolic interarm differences can be excluded with a single pair of measurements. In the population with diabetes, systolic differences may be associated with an increased risk of morbidity and mortality.

Indexed as

Blood PressureAgedArmBlood Pressure DeterminationCardiovascular DiseasesCase-Control StudiesCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2EnglandFemaleHumansIncidenceMaleMiddle AgedOdds Ratio

Identifiers

PMID24667458
OpenAlexW2088670401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.