ArticlePloS one2014
MicroRNA319 positively regulates cold tolerance by targeting OsPCF6 and OsTCP21 in rice (Oryza sativa L.).
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed.
- Functional Characterization of the Oat (International journal of molecular sciences · 2026Article
- Genome-Wide Dissection of the TCP Gene Family in Peach and Expression Analysis Under Drought Stress.International journal of molecular sciences · 2026Article
- Regulatory dynamics of molecular determinants in divergent rice varieties under the influence of nano-structured Zinc: an integrative study of OsbZIP genes and their targeting miRNAs.BMC plant biology · 2026Article
- Transcription factor LchiTCP1 modulates abiotic stress response in arabidopsis.Functional & integrative genomics · 2026Article
- Epigenetic memory and systemic priming: an emerging framework for cold-resilient crops.Plant cell reports · 2026Review
- The BAHD acyltransferase STBR1 confers both saline-alkali tolerance and blast resistance by stabilizing the non-canonical catalase CATA to promote HPlant communications · 2026Article
- Rice and shine: a review of miRNA-mediated responses to abiotic stress inFrontiers in plant science · 2026Review
- Small but big player: the important role of microRNAs in rice.Frontiers in plant science · 2026Review
- Non-coding RNAs in plant stress responses: molecular insights and agricultural applications.Plant biotechnology journal · 2025Review
- Transcription factor ClTCP4 maintains watermelon resilience to drought by stabilizing antioxidant and photosynthetic systems.Plant cell reports · 2025Article
- Rice-specific miR1850.1 targets NPR3 to regulate cold stress response.Plant communications · 2025Article
- Identification and characterization of TCP transcription factor GmTCP670 associated with soybean development.Scientific reports · 2025Article
- Genome-wide identification and expression analysis of the3 Biotech · 2025Article
- Systematic Analysis of thePlants (Basel, Switzerland) · 2025Article
- The Tomato lncRNA47258-miR319b-TCP Module in Biocontrol Bacteria Sneb821 Induced Plants Resistance toPathogens (Basel, Switzerland) · 2025Article
- Non-coding RNAs and their role in plants: prospective omics-tools for improving growth, development and stress tolerance in field crops.Molecular biology reports · 2025Review
- Genome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2025Article
- Transcriptional regulation of miR528-PPO module by miR156 targeted SPLs orchestrates chilling response in banana.Molecular horticulture · 2025Article
- Genome-Wide Identification and Analysis ofInternational journal of molecular sciences · 2024Article
- Functions and applications of RNA interference and small regulatory RNAs.Acta biochimica et biophysica Sinica · 2024Review
45 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
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Abstract
The microRNA319 (miR319) family is conserved among diverse plant species. In rice (Oryza sativa L.), the miR319 gene family is comprised of two members, Osa-miR319a and Osa-miR319b. We found that overexpressing Osa-miR319b in rice resulted in wider leaf blades and delayed development. Here, we focused on the biological function and potential molecular mechanism of the Osa-miR319b gene in response to cold stress in rice. The expression of Osa-miR319b was down-regulated by cold stress, and the overexpression of Osa-miR319b led to an enhanced tolerance to cold stress, as evidenced by higher survival rates and proline content. Also, the expression of a handful of cold stress responsive genes, such as DREB1A/B/C, DREB2A, TPP1/2, was increased in Osa-miR319b transgenic lines. Furthermore, we demonstrated the nuclear localization of the transcription factors, OsPCF6 and OsTCP21, which may be Osa-miR319b-targeted genes. We also showed that OsPCF6 and OsTCP21 expression was largely induced by cold stress, and the degree of induction was obviously repressed in plants overexpressing Osa-miR319b. As expected, the down-regulation of OsPCF6 and OsTCP21 resulted in enhanced tolerance to cold stress, partially by modifying active oxygen scavenging. Taken together, our findings suggest that Osa-miR319b plays an important role in plant response to cold stress, maybe by targeting OsPCF6 and OsTCP21.
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