Evidence map›Paper›PMID 24667133›Full record

ReviewNutrients2014

Metabolic interactions between vitamin A and conjugated linoleic acid.

Gianfranca Carta, Elisabetta Murru, Lina Cordeddu, Berenice Ortiz, Elena Giordano, Martha A Belury, Loredana Quadro, Sebastiano Banni

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Gianfranca CartaDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. giacarta28@hotmail.com.
Elisabetta MurruDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. m.elisabetta.murru@gmail.com.
Lina CordedduDepartment of Bioscience and Nutrition, Karolinska Institute, Stockholm 141 83, Sweden. lina_c@hotmail.it.
Berenice OrtizGerstner Sloan-Kettering Graduate School in Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. OrtizB@mskcc.org.
Elena GiordanoLaboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, Madrid 28049, Spain. elen79@yahoo.it.
Martha A BeluryDepartment of Human Nutrition, Ohio State University, Columbus, OH 43210, USA. belury.1@osu.edu.
Loredana QuadroDepartment of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA. quadro@AESOP.Rutgers.edu.
Sebastiano BanniDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy. banni@unica.it.
University of Cagliari · ITKarolinska Institutet · SEMemorial Sloan Kettering Cancer Center · USRutgers, The State University of New Jersey · USThe Ohio State University · USUniversidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR-α and RXR heterodimer. We also present preliminary data that may position PPAR-α at the crossroads between the metabolism of lipids and vitamin A.

Indexed as

Adipose TissueAnimalsDietary SupplementsDrug InteractionsHumansLinoleic Acids, ConjugatedLiverPPAR alphaRetinol-Binding ProteinsVitamin ALinoleic Acids, ConjugatedPPAR alphaRetinol-Binding ProteinsVitamin A

Identifiers

PMID24667133
PMCPMC3967192
OpenAlexW2035913435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.