Trial reportTrials2014
Launching a salt substitute to reduce blood pressure at the population level: a cluster randomized stepped wedge trial in Peru.
Trial report in Trials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01960972 (Launching a Salt Substitute to Reduce Blood Pressure at the Population Level - Peru), which is not on this map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Launching a Salt Substitute to Reduce Blood Pressure at the Population Level - Peru
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women.The Cochrane database of systematic reviews · 2022Pooled it
- Health Economic Evaluation Alongside Stepped Wedge Trials: A Methodological Systematic Review.PharmacoEconomics · 2021Pooled it
- A systematic review of economic evaluations of population-based sodium reduction interventions.PloS one · 2017Pooled it
- Stepped wedge randomised controlled trials: systematic review of studies published between 2010 and 2014.Trials · 2015Pooled it
- Effect of salt substitution on community-wide blood pressure and hypertension incidence.Nature medicine · 2020Trial
- Optimal Designs in Open-Cohort Longitudinal Cluster Randomized Trials With a Continuous Outcome.Biometrical journal. Biometrische Zeitschrift · 2026Article
- Development of a collaborative chronic care model for management of cardiometabolic disease in low- and middle-income countries.PloS one · 2026Article
- Knowledge, attitudes, and behaviors related to dietary salt intake and the acceptability of salt substitute among the Australian culturally and linguistically diverse community: An online survey.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Comparative analysis of visit and home blood pressure in a pilot trial on the effect of 18% sodium substitute salt on blood pressure.Scientific reports · 2021Article
- Preliminary Experiment on the Effect of 18% Substitute Salt on Home Blood Pressure Variability in Hypertensives.International journal of hypertension · 2021Article
- Effect of a salt-reduction strategy on blood pressure and acceptability among customers of a food concessionaire in Lima, Peru.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2019Article
- Potential use of salt substitutes to reduce blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- TheFrontiers in public health · 2019Article
- How is implementation research applied to advance health in low-income and middle-income countries?BMJ global health · 2019Article
- Parental body mass index and blood pressure are associated with higher body mass index and blood pressure in their adult offspring: a cross-sectional study in a resource-limited setting in northern Peru.Tropical medicine & international health : TM & IH · 2018Article
- Sodium and Potassium Consumption in a Semi-Urban Area in Peru: Evaluation of a Population-Based 24-Hour Urine Collection.Nutrients · 2018Article
- Taste, Salt Consumption, and Local Explanations around Hypertension in a Rural Population in Northern Peru.Nutrients · 2017Article
- Innovative Approaches to Hypertension Control in Low- and Middle-Income Countries.Cardiology clinics · 2017Review
- Association between sleep difficulties as well as duration and hypertension: is BMI a mediator?Global health, epidemiology and genomics · 2017Article
- A Global Perspective on Using Implementation Research to Address Hypertension-Associated Target Organ Damage.Ethnicity & disease · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundControlling hypertension rates and maintaining normal blood pressure, particularly in resource-constrained settings, represent ongoing challenges of effective and affordable implementation in health care. One of the strategies being largely advocated to improve high blood pressure calls for salt reduction strategies. This study aims to estimate the impact of a population-level intervention based on sodium reduction and potassium increase - in practice, introducing a low-sodium, high-potassium salt substitute - on adult blood pressure levels. METHODS/
designThe proposed implementation research study includes two components: Phase 1, an exploratory component, and Phase 2, an intervention component. The exploratory component involves a triangle taste test and a formative research study designed to gain an understanding of the best implementation methods. Phase 2 involves a pragmatic stepped wedge trial design where the intervention will be progressively implemented in several clusters starting the intervention randomly at different times. In addition, we will evaluate the implementation strategy using a cost-effectiveness analysis. DISCUSSION: This is the first project in a Latin-American setting to implement a salt substitution intervention at the population level to tackle high blood pressure. Data generated and lessons learnt from this study will provide a strong platform to address potential interventions applicable to other similar low- and middle-income settings.
trial registrationThis study is registered in ClinicalTrials.gov NCT01960972.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.