Observational studyJournal of clinical hypertension (Greenwich, Conn.)2014
Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes.
Observational study in Journal of clinical hypertension (Greenwich, Conn.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Copeptin and Estimated Insulin Sensitivity in Adults With and Without Type 1 Diabetes: The CACTI Study.Canadian journal of diabetes · 2019Trial
- Uric Acid Is Not Associated With Cardiovascular Health in Youth With Type 1 Diabetes: SEARCH for Diabetes in Youth Study.The Journal of clinical endocrinology and metabolism · 2024Article
- The Management of Diabetes with Hyperuricemia: Can We Hit Two Birds with One Stone?Journal of inflammation research · 2023Review
- Association between the uric acid and hypertension in community-based Chinese population: stratified analysis based on body mass index and age.Journal of thrombosis and thrombolysis · 2021Article
- Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults.Scientific reports · 2019Article
- Association between uric acid, renal haemodynamics and arterial stiffness over the natural history of type 1 diabetes.Diabetes, obesity & metabolism · 2019Article
- Relationship Between Serum Uric Acid and Incident Hypertension in Patients with Type 2 Diabetes.The review of diabetic studies : RDS · 2018Article
- The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort.Medicine · 2017Article
- Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Sex differences in renal and metabolic responses to a high-fructose diet in mice.American journal of physiology. Renal physiology · 2015Article
- Blood pressure and uric acid in diabetes mellitus.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
Corrections and comments
- Commented on by
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults. Little is known about the relationship between serum uric acid and blood pressure in type 1 diabetes and whether it differs from the positive relationship found in nondiabetic adults. The authors assessed the cross-sectional and longitudinal relationships over 6 years between serum uric acid and blood pressure in adults with (35±9 years [n=393]) and without (38±9 years [n=685]) type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. In nondiabetic adults, serum uric acid was associated with systolic blood pressure in multivariable models adjusted for cardiovascular risk factors. In adults with type 1 diabetes, a negative association was observed between serum uric acid and systolic blood pressure after multivariable adjustments. A positive association was observed between serum uric acid and systolic blood pressure in nondiabetic adults. In contrast, an inverse relationship was demonstrated after multivariable adjustments in type 1 diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.