ArticleMagnetic resonance imaging2014
Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T(2) suppression.
Article in Magnetic resonance imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM) of Highly Concentrated Magnetic Nanoparticles: A Comparison Study about Different Sampling Strategies.Molecules (Basel, Switzerland) · 2019Article
- Simultaneous quantitative susceptibility mapping (QSM) and R2* for high iron concentration quantification with 3D ultrashort echo time sequences: An echo dependence study.Magnetic resonance in medicine · 2018Article
- Positive contrast from cells labeled with iron oxide nanoparticles: Quantitation of imaging data.Magnetic resonance in medicine · 2017Article
- Imaging and quantification of iron-oxide nanoparticles (IONP) using MP-RAGE and UTE based sequences.Magnetic resonance in medicine · 2017Article
- Magnetic nanoparticles for precision oncology: theranostic magnetic iron oxide nanoparticles for image-guided and targeted cancer therapy.Nanomedicine (London, England) · 2017Review
- Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR.Physics in medicine and biology · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In order to improve the detection specificity of iron oxide nanoparticles (IONPs) delivered to tumors, we embedded saturation pulses into the sweep imaging using Fourier transformation (SWIFT) sequence to suppress long T(2) tissues and fat. Simulation of the Bloch equation was first conducted to study behavior of the saturation pulses of various lengths under different T(2) and off-resonance conditions. MR experiments were then conducted using in vivo mouse xenografts and a phantom consisting of IONPs, vegetable oil, and explanted tumor specimen, without and with long T(2) suppression under a 7T magnetic field. For the in vivo study, arginine-glycine-aspartate (RGD) coated 10nm IONPs (RGD-IONPs) were delivered to tumors implanted in nude mice through both intra-tumor and intravenous injections. Histological studies confirmed that RGD-IONPs efficiently homed to tumors through RGD-integrin interaction. Compared to conventional SWIFT, the proposed method resulted in sufficient suppression on long T(2) species but less influence on short T(2) species. For both the in vivo and ex vivo studies, significantly improved contrast-to-noise ratio (CNR) was achieved between the IONPs and the long T(2) species.
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