Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2015
25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Associations between vitamin D status and biomarkers linked with inflammation in patients with asthma: a systematic review and meta-analysis of interventional and observational studies.Respiratory research · 2024Pooled it
- A Meta-Analysis on Vitamin D Supplementation and Asthma Treatment.Frontiers in nutrition · 2022Pooled it
- A 12-week double-blind randomised controlled trial investigating the effect of dietary supplementation with 125The British journal of nutrition · 2024Trial
- Effect of age and body mass index on vitamin D level in children with asthma in Riyadh.Scientific reports · 2021Trial
- Nutrition as a Modifiable Factor in Optimizing Respiratory Health: Evidence from Pulmonary Function Tests.Children (Basel, Switzerland) · 2026Review
- Serum Vitamin D Profiles of Children with Asthma in Southwest Saudi: A Comparative Cross-Sectional Study.International journal of general medicine · 2024Article
- Basis of preventive and non-pharmacological interventions in asthma.Frontiers in public health · 2023Review
- Asthma and vitamin D in Brazilian adolescents: Study of Cardiovascular Risks in Adolescents (ERICA).Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2021Article
- The role of nutrition in asthma prevention and treatment.Nutrition reviews · 2020Review
- The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.Pediatric allergy, immunology, and pulmonology · 2019Article
- Association of vitamin D receptor expression with inflammatory changes and prognosis of asthma.Experimental and therapeutic medicine · 2018Article
- Review
- Article
- Prevalence and Associated Risk Factors of Bronchial Asthma in Children in Santo Domingo, Dominican Republic.Cureus · 2018Article
- Seasonal variation of asthma control, lung function tests and allergic inflammation in relation to vitamin D levels: a prospective annual study.Postepy dermatologii i alergologii · 2018Article
- Kawasaki disease: a comprehensive review.Archives of medical sciences. Atherosclerotic diseases · 2018Article
- Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents.BioMed research international · 2018Article
- Free 25(OH)D concentrations are associated with atopy and lung function in children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
- Vitamin D deficiency among smear positive pulmonary tuberculosis patients and their tuberculosis negative household contacts in Northwest Ethiopia: a case-control study.Annals of clinical microbiology and antimicrobials · 2017Article
- A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine.Journal of lipid research · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundVitamin D deficiency may be associated with an increased risk of asthma.
objectiveWe studied the association between 25-hydroxy (25-OH) vitamin D deficiency and asthma prevalence in two Peruvian populations close to the equator but with disparate degrees of urbanization.
methodsWe conducted a population-based study in 1441 children in two communities in Peru, of which 1134 (79%) provided a blood sample for 25-OH vitamin D analysis.
resultsIn these 1134 children, mean age was 14.8 years; 52% were boys; asthma and atopy prevalence was 12% in Lima vs. 3% in Tumbes (P < 0.001) and 59% in Lima vs. 41% in Tumbes (P < 0.001), respectively; and, mean 25-OH vitamin D level was 20.8 ng/mL in Lima vs. 30.1 ng/mL in Tumbes (P < 0.001). Prevalence of 25-OH vitamin D deficiency (< 20 ng/mL) was 47% in Lima vs. 7% in Tumbes (P < 0.001). In multi-variable logistic regression, we found that lower 25-OH vitamin D levels were associated with an increased odds of asthma (OR = 1.7 per each 10 ng/mL decrease in 25-OH vitamin D levels, 95% CI 1.2-2.6; P < 0.01). In stratified analyses, the association between lower 25-OH vitamin D levels and asthma was limited to children with atopy (OR = 2.2, 95% CI 1.3-3.6) and not in those without atopy (OR = 0.9, 95% CI 0.5-2.0). We did not find associations between 25-OH vitamin D levels and other clinical biomarkers for asthma, including exhaled nitric oxide, total serum IgE and pulmonary function. CONCLUSION AND CLINICAL RELEVANCE: Both asthma and 25-OH vitamin D deficiency were common among children living in Lima (latitude = 12.0 °S) but not among those in Tumbes (3.6 °S). The relationship between 25-OH vitamin D deficiency and asthma was similar in both sites and was limited among children with atopy. Future supplementation trials may need to consider stratification by atopy at the time of design.
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