ArticleNutrition research reviews2014
Misconceptions about fructose-containing sugars and their role in the obesity epidemic.
Article in Nutrition research reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies.BMJ (Clinical research ed.) · 2018Pooled it
- Energy compensation following consumption of sugar-reduced products: a randomized controlled trial.European journal of nutrition · 2016Trial
- Trial
- Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease.Endocrine reviews · 2025Review
- Fructose-Induced Metabolic Dysfunction Is Dependent on the Baseline Diet, the Length of the Dietary Exposure, and Sex of the Mice.Nutrients · 2024Article
- Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD.The Journal of nutritional biochemistry · 2023Review
- High Fructose Causes More Prominent Liver Steatohepatitis with Leaky Gut Similar to High Glucose Administration in Mice and Attenuation byNutrients · 2023Article
- Agave Syrup: Chemical Analysis and Nutritional Profile, Applications in the Food Industry and Health Impacts.International journal of environmental research and public health · 2022Review
- Dietary fructose and its association with the metabolic syndrome in Lebanese healthy adults: a cross-sectional study.Diabetology & metabolic syndrome · 2022Article
- Article
- Article
- Ultraprocessed Food: Addictive, Toxic, and Ready for Regulation.Nutrients · 2020Article
- Carotenoids Inhibit Fructose-Induced Inflammatory Response in Human Endothelial Cells and Monocytes.Mediators of inflammation · 2020Article
- Saccharide Characteristics and Their Potential Health Effects in Perspective.Frontiers in nutrition · 2020Review
- Review
- Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals.Antioxidants (Basel, Switzerland) · 2019Review
- Intakes and sources of dietary sugars and their association with metabolic and inflammatory markers.Clinical nutrition (Edinburgh, Scotland) · 2018Observational
- Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease.European heart journal · 2018Review
- Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.The Journal of biological chemistry · 2018Article
- The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.Cell metabolism · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A causal role of fructose intake in the aetiology of the global obesity epidemic has been proposed in recent years. This proposition, however, rests on controversial interpretations of two distinct lines of research. On one hand, in mechanistic intervention studies, detrimental metabolic effects have been observed after excessive isolated fructose intakes in animals and human subjects. On the other hand, food disappearance data indicate that fructose consumption from added sugars has increased over the past decades and paralleled the increase in obesity. Both lines of research are presently insufficient to demonstrate a causal role of fructose in metabolic diseases, however. Most mechanistic intervention studies were performed on subjects fed large amounts of pure fructose, while fructose is ordinarily ingested together with glucose. The use of food disappearance data does not accurately reflect food consumption, and hence cannot be used as evidence of a causal link between fructose intake and obesity. Based on a thorough review of the literature, we demonstrate that fructose, as commonly consumed in mixed carbohydrate sources, does not exert specific metabolic effects that can account for an increase in body weight. Consequently, public health recommendations and policies aiming at reducing fructose consumption only, without additional diet and lifestyle targets, would be disputable and impractical. Although the available evidence indicates that the consumption of sugar-sweetened beverages is associated with body-weight gain, and it may be that fructose is among the main constituents of these beverages, energy overconsumption is much more important to consider in terms of the obesity epidemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.