ArticleClinical and experimental immunology2014
Single cell-derived clones from human adipose stem cells present different immunomodulatory properties.
Article in Clinical and experimental immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
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- Immunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graftWorld journal of stem cells · 2020Article
- Downregulation of microRNA‑143 promotes osteogenic differentiation of human adipose‑derived mesenchymal stem cells through the k‑Ras/MEK/ERK signaling pathway.International journal of molecular medicine · 2020Article
- Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials.Bioelectricity · 2020Article
- Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes.Stem cell research & therapy · 2019Review
- Dad's Snoring May Have Left Molecular Scars in Your DNA: the Emerging Role of Epigenetics in Sleep Disorders.Molecular neurobiology · 2018Review
- Improvement of Mesenchymal Stem Cell Immunomodulatory Properties by Heat-KilledFrontiers in molecular neuroscience · 2018Article
- Differences of Clonogenic Mesenchymal Stem Cells on Immunomodulation of Lymphocyte Subsets.Journal of immunology research · 2018Article
- Comparative Analysis of Media and Supplements on Initiation and Expansion of Adipose-Derived Stem Cells.Stem cells translational medicine · 2016Article
- Ex vivo identification and characterization of a population of CD13(high) CD105(+) CD45(-) mesenchymal stem cells in human bone marrow.Stem cell research & therapy · 2015Article
- DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells.Scientific reports · 2015Article
- Obesity and weight loss could alter the properties of adipose stem cells?World journal of stem cells · 2015Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human adipose mesenchymal stem cells are a heterogeneous population, where cell cultures derived from single-cell-expanded clones present varying degrees of differential plasticity. This work focuses on the immunomodulatory/anti-inflammatory properties of these cells. To this end, five single-cell clones were isolated (generally called 1.X and 3.X) from two volunteers. Regarding the expression level of the lineage-characteristic surface antigens, clones 1·10 and 1·22 expressed the lowest amounts, while clones 3·10 and 3·5 expressed more CD105 than the rest and clone 1·7 expressed higher amounts of CD73 and CD44. Regarding cytokine secretion, all clones were capable of spontaneously releasing high levels of interleukin (IL)-6 and low to moderate levels of IL-8. These differences can be explained in part by the distinct methylation profile exhibited by the clones. Furthermore, and after lipopolysaccharide stimulation, clone 3.X produced the highest amounts of proinflammatory cytokines such as IL-1β, while clones 1·10 and 1·22 highly expressed IL-4 and IL-5. In co-culture experiments, clones 1.X are, together, more potent inhibitors than clones 3.X for proliferation of total, CD3(+) T, CD4(+) T and CD8(+) T lymphocytes and natural killer (NK) cells. The results of this work indicate that the adipose stem cell population is heterogeneous in cytokine production profile, and that isolation, characterization and selection of the appropriate cell clone is a more exact method for the possible treatment of different patients or pathologies.
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