ArticleJournal of cognitive neuroscience2014
Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects.
Article in Journal of cognitive neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Article
- New perspectives on the basal forebrain cholinergic system in Alzheimer's disease.Neuroscience and biobehavioral reviews · 2023Review
- Disrupted Choline Clearance and Sustained Acetylcholine ReleaseThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071.Psychopharmacology · 2021Article
- α4β2Annals of neurology · 2021Article
- Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits.Pharmacology & therapeutics · 2021Review
- Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Article
- Addiction vulnerability and the processing of significant cues: Sign-, but not goal-, tracker perceptual sensitivity relies on cue salience.Behavioral neuroscience · 2020Article
- Forebrain Cholinergic Signaling: Wired and Phasic, Not Tonic, and Causing Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Losing Money and Motivation: Effects of Loss Incentives on Motivation and Metacognition in Younger and Older Adults.Frontiers in psychology · 2020Article
- Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071.Psychopharmacology · 2020Article
- Cholinergic double duty: cue detection and attentional control.Current opinion in psychology · 2019Review
- Repetitive mild concussion in subjects with a vulnerable cholinergic system: Lasting cholinergic-attentional impairments in CHT+/- mice.Behavioral neuroscience · 2019Article
- Poor Sleep Quality and Compromised Visual Working Memory Capacity.Journal of the International Neuropsychological Society : JINS · 2019Article
- Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson's disease.Psychopharmacology · 2019Article
- Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease.NeuroImage · 2019Article
- The cortical cholinergic system contributes to the top-down control of distraction: Evidence from patients with Parkinson's disease.NeuroImage · 2019Article
- Prenatal Protein Malnutrition Produces Resistance to Distraction Similar to Noradrenergic Deafferentation of the Prelimbic Cortex in a Sustained Attention Task.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Both the passage of time and external distraction make it difficult to keep attention on the task at hand. We tested the hypothesis that time-on-task and external distraction pose independent challenges to attention and that the brain's cholinergic system selectively modulates our ability to resist distraction. Participants with a polymorphism limiting cholinergic capacity (Ile89Val variant [rs1013940] of the choline transporter gene SLC5A7) and matched controls completed self-report measures of attention and a laboratory task that measured decrements in sustained attention with and without distraction. We found evidence that distraction and time-on-task effects are independent and that the cholinergic system is strongly linked to greater vulnerability to distraction. Ile89Val participants reported more distraction during everyday life than controls, and their task performance was more severely impacted by the presence of an ecologically valid video distractor (similar to a television playing in the background). These results are the first to demonstrate a specific impairment in cognitive control associated with the Ile89Val polymorphism and add to behavioral and cognitive neuroscience studies indicating the cholinergic system's critical role in overcoming distraction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.