Evidence map›Paper›PMID 24665916›Full record

ArticlePaediatric and perinatal epidemiology2014

Methodology for establishing a population-based birth cohort focusing on couple fertility and children's development, the Upstate KIDS Study.

Germaine M Buck Louis, Mary L Hediger, Erin M Bell, Christopher A Kus, Rajeshwari Sundaram, Alexander C McLain, Edwina Yeung, Elaine A Hills, Marie E Thoma, Charlotte M Druschel

Registry-linked trialAbstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03106493 (Upstate New York Infant Development Screening Program), which is not on this map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03106493 completednot on this map

Upstate New York Infant Development Screening Program

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2008 to 2019Enrolled6,171ConditionsObesity, Blood Pressure, Motor Delay, Developmental DelayArmsNone (observational)
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Toddler diet quality: a factor associated with childhood growth?International journal of obesity (2005) · 2026
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Neighborhood opportunity and residential instability: associations with mental health in middle childhood.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Article
  9. Article
  10. Article
  11. Cohort Profile: Upstate KIDS study.International journal of epidemiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Germaine M Buck LouisDivision of Intramural Population Health Research, Rockville, MD.
Mary L Hediger
Erin M Bell
Christopher A Kus
Rajeshwari Sundaram
Alexander C McLain
Edwina Yeung
Elaine A Hills
Marie E Thoma
Charlotte M Druschel
Office of Extramural Research · USNew York State Department of Health · USUniversity at Albany, State University of New York · USUniversity of South Carolina · US

Funding

Infertility Treatment, Child Growth and Development Through Age Three YearsZIAHD008826 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2009 to 2025
$9.4M
Developmental Infrastructure CoreR24HD044943 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI SHAW, BENJAMIN A · 2004 to 2016
$4.8M
Statistical Modeling of Human FecundityZIAHD008883 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SUNDARAM, RAJESHWARI · 2009 to 2025
$3.6M
NICHD NIH HHS HHSN267200700019CNICHD NIH HHS HHSN275201200005CNICHD NIH HHS R24 HD044943
6 · The paper itself

Abstract

backgroundCritical data gaps remain regarding infertility treatment and child development. We assessed the utility of a birth certificate registry for developing a population cohort aimed at answering such questions.

methodsWe utilised the Upstate New York livebirth registry (n = 201,063) to select births conceived with (n = 4024) infertility treatment or exposed infants, who were then frequency-matched by residence to a random sample of infants conceived without (n = 14,455) treatment or unexposed infants, 2008-10. Mothers were recruited at 2-4 months postpartum and queried about their reproductive histories, including infertility treatment for comparison with birth certificate data. Overall, 1297 (32%) mothers of exposed and 3692 of unexposed (26%) infants enrolled.

resultsTwins represented 22% of each infant group. The percentage of infants conceived with/without infertility treatment was similar whether derived from the birth registry or maternal report: 71% none, 16% drugs or intrauterine insemination, and 14% assisted reproductive technologies (ART). Concordant reporting between the two data sources was 93% for no treatment, 88% for ART, and 83% for fertility drugs, but differed by plurality. Exposed infants had slightly (P < 0.01) earlier gestations than unexposed infants (38.3 ± 2.8 and 38.7 ± 2.7 weeks, respectively) based upon birth certificates but not maternal report (38.7 ± 2.7 and 38.7 ± 2.9, respectively). Conversely, mean birthweight was comparable using birth certificates (3157 ± 704 and 3194 ± 679 g, respectively), but differed using maternal report (3167 ± 692 and 3224 ± 661, respectively P < 0.05).

conclusionsThe birth certificate registry is a suitable sampling framework as measured by concordance with maternally reported infertility treatment. Future efforts should address the impact of factors associated with discordant reporting on research findings.

Indexed as

Birth CertificatesChild DevelopmentFertilityAdultBirth RateChildChild, PreschoolFamily CharacteristicsFemaleHumansInfantInfant, NewbornMaleMultiple Birth OffspringNew YorkPopulation Surveillanceassisted reproductive technologieschildrenfecundityinfertilityin vitro fertilization

Identifiers

PMID24665916
PMCPMC4563277
OpenAlexW2145000720

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.