ArticleTissue barriers2013
ARHGEF11, a regulator of junction-associated actomyosin in epithelial cells.
Article in Tissue barriers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Increased tissue tension caused by depletion of CLDN3 in the non-neural ectoderm causes neural tube defects in chick embryos.Journal of cell science · 2026Article
- Systemic and proximal tubule specific knockout ofPhysiological genomics · 2026Article
- Genome-wide study for signatures of selection identifies genomic regions and candidate genes associated with milk traits in sheep.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Article
- Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function.Scientific reports · 2021Article
- Formation and contraction of multicellular actomyosin cables facilitate lens placode invagination.Developmental biology · 2020Article
- Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity.Cell reports · 2018Article
- The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells.Oncotarget · 2017Article
- Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function.Experimental cell research · 2017Review
- Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms.Tissue barriers · 2013Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial cells form organized sheets to protect underlying tissues and maintain the physiological environment by the assembly of tight junctions (TJs) and adherens junctions (AJs), which mainly regulate paracellular molecular passage and selective cell-cell adhesion, respectively. At the cytoplasmic surface, TJs and AJs associate with a specific actomyosin cytoskeletal structure called the perijunctional actomyosin ring (PJAR), which encircles cells in a belt-like manner. ZO family proteins play important roles in regulating TJ and PJAR organization. We recently found that ARHGEF11, a member of the RGS-RhoGEF family of proteins, associates with TJs by binding to ZO-1. ARHGEF11 mediates ZO-1-dependent junction assembly and barrier formation in mammary epithelial cells. Another recent study demonstrated that ARHGEF11-dependent apical actomyosin contraction is coupled to planar cell polarity signaling in neuroepithelial cells for the control of neural tube formation. These findings suggest that ARHGEF11 generally regulates apical junctions and junction-associated actomyosin in various epithelial tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.