ArticleTissue barriers2013
Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues.
Article in Tissue barriers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Conditions that promote transcellular neutrophil migration in vivo.Scientific reports · 2024Article
- β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.Frontiers in immunology · 2021Review
- Update on the role of endothelial cells in trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Review
- The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Review
- Targeting Inflammation to Improve Tumor Drug Delivery.Trends in cancer · 2017Review
- Leukocyte transendothelial migration: A local affair.Small GTPases · 2017Review
- Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules.Nature communications · 2016Article
- Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras.The Journal of cell biology · 2015Article
- Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.Molecular and cellular biology · 2014Article
- Similarities and differences in the regulation of leukocyte extravasation and vascular permeability.Seminars in immunopathology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The passage of leukocytes across the blood vessel wall is a fundamental event in the inflammatory response. During the last decades, there has been significant progress in understanding the molecular mechanisms involved in leukocyte transmigration. However, it is still a matter of debate whether leukocytes migrate paracellularly or transcellularly through an endothelial cell layer. We could recently show that a VE-cadherin-α-catenin fusion protein locks endothelial junctions in the skin and strongly reduces leukocyte diapedesis in lung, skin and cremaster, establishing the paracellular route as the major transmigration pathway in these tissues. However, the homing of naïve lymphocytes into lymph nodes and extravasation of neutrophils in the inflamed peritoneum were not affected by VE-cadherin-α-catenin. This unexpected heterogeneity of the diapedesis process in different tissues as well as the complexity and dynamics of the cadherin-catenin complex in regulating endothelial junctions will be discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.