ArticleRegeneration (Oxford, England)2014
Regeneration of reptilian scales after wounding: neogenesis, regional difference, and molecular modules.
Article in Regeneration (Oxford, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of topical insulin on second-intention wound healing in the red-eared slider turtle (Trachemys scripta elegans) - a controlled study.BMC veterinary research · 2017Trial
- Heart ventricle regeneration in the lizard Eublepharis macularius, the leopard gecko.NPJ Regenerative medicine · 2026Article
- Microscopic and ultrastructural observations on the regenerating scales of the lizard Podarcis muralis clarify the origin of the micro-ornamentation.Protoplasma · 2025Article
- Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth.Developmental biology · 2025Review
- Probe Sequencing Analysis of Regenerating Lizard Tails Indicates Crosstalk Among Osteoclasts, Epidermal Cells, and Fibroblasts.Journal of developmental biology · 2025Article
- Wound-Induced Regeneration in Feather Follicles: A Stepwise Strategy to Regenerate Stem Cells.Journal of developmental biology · 2025Article
- Bioinspired Strategies for Wound Regeneration.Cold Spring Harbor perspectives in biology · 2023Review
- Molecular and Cellular Characterization of Avian Reticulate Scales Implies the Evo-Devo Novelty of Skin Appendages in Foot Sole.Journal of developmental biology · 2023Article
- Evolutionary bedfellows: Reconstructing the ancestral state of autotomy and regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Article
- PGE2 facilitates tail regeneration via activation of Wnt signaling in Gekko japonicus.Journal of molecular histology · 2019Article
- Comprehensive molecular and cellular studies suggest avian scutate scales are secondarily derived from feathers, and more distant from reptilian scales.Scientific reports · 2018Article
- VEGF, FGF-2 and TGFβ expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles.Journal of anatomy · 2018Article
- Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion.Molecular biology and evolution · 2018Article
- Wound healing, cellular regeneration and plasticity: the elegans way.The International journal of developmental biology · 2018Review
- Regeneration of dermal patterns from the remaining pigments after surgery in Eublepharis macularius (a case report).BMC veterinary research · 2016Article
- Identification of Biomarkers for Footpad Dermatitis Development and Wound Healing.Frontiers in cellular and infection microbiology · 2016Article
- Scar-free cutaneous wound healing in the leopard gecko, Eublepharis macularius.Journal of anatomy · 2015Article
- Deciphering principles of morphogenesis from temporal and spatial patterns on the integument.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Lizard skin can produce scales during embryonic development, tail regeneration, and wound healing; however, underlying molecular signaling and extracellular matrix protein expression remains unknown. We mapped cell proliferation, signaling and extracellular matrix proteins in regenerating and developing lizard scales in different body regions with different wound severity. Following lizard tail autotomy (self-amputation), de novo scales regenerate from regenerating tail blastema. Despite topological differences between embryonic and adult scale formation, asymmetric cell proliferation produces the newly formed outer scale surface. Regionally different responses to wounding were observed; open wounds induced better scale regeneration from tail skin than trunk skin. Molecular studies suggest NCAM enriched dermal regions exhibit higher cell proliferation associated with scale growth. β-catenin may be involved in epidermal scale differentiation. Dynamic tenascin-C expression suggests its involvement in regeneration. We conclude that different skin regions exhibit different competence for de novo scale formation. While cellular and morphogenetic paths differ during development and regeneration of lizard scale formation, they share general proliferation patterns, epithelial-mesenchymal interactions and similar molecular modules composed of adhesion and extracellular matrix molecules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.