ArticleThe Journal of physiology2014
Nucleus accumbens neuronal maturation differences in young rats bred for low versus high voluntary running behaviour.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats.Journal of functional morphology and kinesiology · 2022Article
- Temporal and bidirectional influences of estradiol on voluntary wheel running in adult female and male rats.Hormones and behavior · 2020Article
- Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.American journal of physiology. Cell physiology · 2019Article
- Phosphorylation of CRY1 Serine 71 Alters Voluntary Activity but Not Circadian Rhythms In Vivo.Journal of biological rhythms · 2019Article
- Rats Selectively Bred for High Voluntary Physical Activity Behavior are Not Protected from the Deleterious Metabolic Effects of a Western Diet When Sedentary.Current developments in nutrition · 2019Article
- Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior.Scientific reports · 2019Article
- Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior.Molecular neurobiology · 2019Article
- Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC.Medicine and science in sports and exercise · 2018Review
- Previously undescribed vitamin D C-3 epimer occurs in substantial amounts in the blood of cats.Journal of feline medicine and surgery · 2018Article
- Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Genetic architecture of motives for leisure-time physical activity: a twin study.Scandinavian journal of medicine & science in sports · 2017Article
- Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.Physiological reviews · 2017Review
- Sex-dependent differences in voluntary physical activity.Journal of neuroscience research · 2017Review
- Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity.The Journal of physiology · 2017Article
- Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running.Drug and alcohol dependence · 2016Article
- Speed-Dependent Modulation of the Locomotor Behavior in Adult Mice Reveals Attractor and Transitional Gaits.Frontiers in neuroscience · 2016Article
- Comparative adaptations in oxidative and glycolytic muscle fibers in a low voluntary wheel running rat model performing three levels of physical activity.Physiological reports · 2015Article
- Cocaine-induced locomotor activity in rats selectively bred for low and high voluntary running behavior.Psychopharmacology · 2015Article
- Running for reward: a matter of the mature mind.The Journal of physiology · 2014Article
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11 authors at 2 institutions in 1 country.
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Abstract
We compared the nucleus accumbens (NAc) transcriptomes of generation 8 (G8), 34-day-old rats selectively bred for low (LVR) versus high voluntary running (HVR) behaviours in rats that never ran (LVR(non-run) and HVR(non-run)), as well as in rats after 6 days of voluntary wheel running (LVR(run) and HVR(run)). In addition, the NAc transcriptome of wild-type Wistar rats was compared. The purpose of this transcriptomics approach was to generate testable hypotheses as to possible NAc features that may be contributing to running motivation differences between lines. Ingenuity Pathway Analysis and Gene Ontology analyses suggested that 'cell cycle'-related transcripts and the running-induced plasticity of dopamine-related transcripts were lower in LVR versus HVR rats. From these data, a hypothesis was generated that LVR rats might have less NAc neuron maturation than HVR rats. Follow-up immunohistochemistry in G9-10 LVR(non-run) rats suggested that the LVR line inherently possessed fewer mature medium spiny (Darpp-32-positive) neurons (P < 0.001) and fewer immature (Dcx-positive) neurons (P < 0.001) than their G9-10 HVR counterparts. However, voluntary running wheel access in our G9-10 LVRs uniquely increased their Darpp-32-positive and Dcx-positive neuron densities. In summary, NAc cellularity differences and/or the lack of running-induced plasticity in dopamine signalling-related transcripts may contribute to low voluntary running motivation in LVR rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.