Evidence map›Paper›PMID 24664811›Full record

Trial reportInternational journal of geriatric psychiatry2014

Social support in late life mania: GERI-BD.

John L Beyer, Rebecca L Greenberg, Patricia Marino, Martha L Bruce, Rayan K Al Jurdi, Martha Sajatovic, Laszlo Gyulai, Benoit H Mulsant, Ariel Gildengers, Robert C Young

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in International journal of geriatric psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00254488 (Acute Pharmacotherapy of Late-Life Mania), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00254488 phase4completednot on this map

Acute Pharmacotherapy of Late-Life Mania (GERI-BD)

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2005 to 2011Enrolled224ConditionsBipolar Disorder, ManiaArmsLithium (LI), Divalproex (DV)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Assessing bipolar disorder in the older adult: the GERI-BD toolbox.International journal of geriatric psychiatry · 2018
    Trial
  2. Review
  3. Late-life psychosis: diagnosis and treatment.Current psychiatry reports · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

John L BeyerDuke University Medical Center, Durham, NC, USA.
Rebecca L Greenberg
Patricia Marino
Martha L Bruce
Rayan K Al Jurdi
Martha Sajatovic
Laszlo Gyulai
Benoit H Mulsant
Ariel Gildengers
Robert C Young
Cornell University · USBaylor College of Medicine · USDuke Medical Center · USPittsburg State University · USUniversity Hospitals of Cleveland · USUniversity of Pennsylvania Health System · USUniversity of Toronto · CA

Funding

Acute Pharmacotherapy of Late-Life Mania-Study Coordinating CenterU01MH074511 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2005 to 2009
$1.3M
Treatment of Bipolar Disorder in Old AgeK02MH067028 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2003 to 2013
$1.2M
Acute and Continuation Treatment in Late Life ManiaU01MH068848 · NIMH · DUKE UNIVERSITY · PI BEYER, JOHN LESLIE · 2005 to 2009
$1.1M
Acute Pharmacotherapy of Late-Life ManiaU01MH068847 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2005 to 2009
$650k
NIMH NIH HHS K02 MH067028NIMH NIH HHS U01 MH068847NIMH NIH HHS U01 MH068848NIMH NIH HHS U01 MH074511
6 · The paper itself

Abstract

objectiveUsing the database of the National Institute of Mental Health-sponsored acute treatment of late life mania study (GERI-BD), we assessed the role of social support in the presentation of late life bipolar mania.

methodsIn the first 100 subjects randomized in geriatric BD, we explored the demographic, clinical, and social support characteristics (assessed using the Duke Social Support Index) and aspects of manic presentation. We selected two dependent variables: symptom severity, as determined by the Young Mania Rating Scale (YMRS) at baseline, and duration of episode. We selected nine potential independent variables on the basis of Pearson correlation coefficients. We derived two final models using multiple regression analysis employing an iterative process.

resultsIn our severity model, being married was associated with a higher YMRS score (p = 0.05), whereas higher social interaction scores with non-family members were associated with a lower YMRS score (p = 0.011). In the episode duration model, longer duration was associated with a higher Hamilton Depression Rating Scale score (p = 0.03) and higher social interaction scores with non-family members (p = 0.0003), younger age (p = 0.04), higher number of persons in one's family social network (p = 0.017), and higher instrumental support scores (p = 0.0062).

conclusionsIn late life mania, more social interaction with one's community appears to be associated with less severe symptoms at presentation for treatment, however, it can also be associated with slightly longer the duration of episode. Two aspects of the Duke Social Support Index are associated with a shorter episode duration prior to seeking treatment: being part of a larger family network and a having a higher level of instrumental support prior to treatment. The Instrumental Support Subscale measures the degree of assistance that is available for the respondent in performing daily tasks. These findings suggest that in older adults with BD, close social interactions and support are important in limiting the length of the illness episode prior to treatment. Social interactions involving non-family members may be less important in moderating the intensity of the symptoms at presentation.

Indexed as

Social SupportAgedAged, 80 and overAntimanic AgentsAntipsychotic AgentsBipolar DisorderCross-Sectional StudiesFemaleHumansMaleMarital StatusMiddle AgedPsychiatric Status Rating ScalesRisk FactorsUnited StatesAntimanic AgentsAntipsychotic Agentsbipolar disorderelderlymaniasocial support

Identifiers

PMID24664811
PMCPMC4545672
OpenAlexW1680904346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.