ArticleAge (Dordrecht, Netherlands)2014
Glomerular filtration rate in the elderly and in the oldest old: correlation with frailty and mortality.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive, functional, physical, and nutritional status of the oldest old encountered in primary care: a systematic review.BMC family practice · 2020Pooled it
- A Systematic Review Comparing the Prognostic Role of eGFR According to CKD-EPI and Older Age Validated Equations in Older Adults.Kidney medicine · 2025Article
- Article
- Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis.Frontiers in medicine · 2024Review
- Renal function assessment in older people: comparative analysis of estimation equation with serum creatinine.Frontiers in medicine · 2024Article
- Changes in Kidney Function After Diagnosis of Advanced Heart Failure.Journal of cardiac failure · 2023Article
- Prevalence and associated risk factors for chronic kidney disease in the elderly physically disabled population in Shanghai, China: a cross-sectional study.BMC public health · 2023Article
- Development and Validation of a Novel Risk Score for All-Cause Mortality Risk Stratification Prior to Permanent Pacemaker Implantation in Octogenarians or Older.Medicina (Kaunas, Lithuania) · 2023Article
- Does Estimated Glomerular Filtration Rate Predict In-Hospital Mortality in Acutely Unwell Hospitalized Oldest Old?Geriatrics (Basel, Switzerland) · 2022Article
- Clinical and Prognostic Implications of Estimating Glomerular Filtration Rate by Three Different Creatinine-Based Equations in Older Nursing Home Residents.Frontiers in medicine · 2022Article
- Design and methodology of the chronic kidney disease as a dysmetabolic determinant of disability among older people (CKD-3D) study: a multicenter cohort observational study.Aging clinical and experimental research · 2021Observational
- The effects of single and a combination of determinants of anaemia in the very old: results from the TULIPS consortium.BMC geriatrics · 2021Article
- Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Observational
- Trajectories of self-rated health in an older general population and their determinants: the Lifelines Cohort Study.BMJ open · 2020Article
- Predictors of long-term survival prior to permanent pacemaker implantation in octogenarians or older.Aging clinical and experimental research · 2019Article
- Relations of established aging biomarkers (IL-6, D-dimer, s-VCAM) to glomerular filtration rate and mortality in community-dwelling elderly adults.Clinical kidney journal · 2018Article
- Severe Decline of Estimated Glomerular Filtration Rate Associates with Progressive Cognitive Deterioration in the Elderly: A Community-Based Cohort Study.Scientific reports · 2017Article
- Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal.American journal of nephrology · 2016Article
- Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The equations for estimating kidney function have become very popular in the last decade. However, the clinical and prognostic meaning of these measures may be very different in older populations. Two cohorts of people aged 65-89 years (older sample) and 90 or more (oldest old sample) were used to investigate the prognostic significance of estimated glomerular filtration rate (eGFR). Additionally, we also investigated whether combining frailty and eGFR may improve the accuracy of frailty in predicting mortality. We found that lower eGFR values were significantly more frequent among frail subjects in both groups. eGFR < 30 was associated with increased risk for all-cause mortality either in subjects aged 65-89 years (HR = 3.71, 95% CI = 1.23-11.2) or in those aged 90 or more (HR = 1.53, 95% CI = 1.05-2.23). In the latter group, a not significant trend for increasing mortality was also observed among people with eGFR > 60 (HR = 1.28, 95% CI = 0.72-2.26). In addition, the oldest old subjects with eGFR > 60 and eGFR < 30 had the lowest hand-grip strength and ADL values. Combining eGFR and frailty status significantly improved the accuracy of frailty in predicting mortality only in the older sample. In conclusion, a U-shaped relationship exists between eGFR and mortality in the oldest old, but not in older individuals. Our findings suggest that eGFR needs to be adjusted for muscle mass/physical performance when estimating kidney function in people aged 90 or more. Nevertheless, in subjects aged 65-89 years, eGFR may improve the accuracy of frailty status in predicting prognosis, thus suggesting that eGFR may represent an additional dimension of frailty syndrome.
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