ArticleMagnetic resonance in medicine2014
Quantifying iron-oxide nanoparticles at high concentration based on longitudinal relaxation using a three-dimensional SWIFT Look-Locker sequence.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Compressed sensing acceleration of radial 3-D alternating Look-LockerMagnetic resonance in medicine · 2025Article
- Iron oxide based magnetic nanoparticles for hyperthermia, MRI and drug delivery applications: a review.RSC advances · 2025Review
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- High-resolution 3D ultra-short echo time MRI with Rosette k-space pattern for brain iron content mapping.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023Article
- Thermal Analyses of Nanowarming-Assisted Recovery of the Heart From Cryopreservation by Vitrification.Journal of heat transfer · 2022Article
- Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment.Scientific reports · 2021Article
- Sensitive detection of extremely small iron oxide nanoparticles in living mice using MP2RAGE with advanced image co-registration.Scientific reports · 2021Article
- Analysis Protocols for MRI Mapping of Renal TMethods in molecular biology (Clifton, N.J.) · 2021Article
- Experimental Protocols for MRI Mapping of Renal TMethods in molecular biology (Clifton, N.J.) · 2021Article
- The impact of data selection and fitting on SAR estimation for magnetic nanoparticle heating.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020Article
- Imaging the distribution of iron oxide nanoparticles in hypothermic perfused tissues.Magnetic resonance in medicine · 2020Article
- To measure TJournal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Preparation of Scalable Silica-Coated Iron Oxide Nanoparticles for Nanowarming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI.Journal of neuro-oncology · 2019Article
- Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM) of Highly Concentrated Magnetic Nanoparticles: A Comparison Study about Different Sampling Strategies.Molecules (Basel, Switzerland) · 2019Article
- Imaging of a high concentration of iron labeled cells with positive contrast in a rat knee.Magnetic resonance in medicine · 2019Article
- From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer.Annual review of biomedical engineering · 2018Review
- Simultaneous quantitative susceptibility mapping (QSM) and R2* for high iron concentration quantification with 3D ultrashort echo time sequences: An echo dependence study.Magnetic resonance in medicine · 2018Article
- Establishing the overlap of IONP quantification with echo and echoless MR relaxation mapping.Magnetic resonance in medicine · 2018Article
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7 authors.
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Abstract
purposeIron-oxide nanoparticles (IONPs) have proven utility as contrast agents in many MRI applications. Previous quantitative IONP mapping has been performed using mainly T2 * mapping methods. However, in applications requiring high IONP concentrations, such as magnetic nanoparticles based thermal therapies, conventional pulse sequences are unable to map T2 * because the signal decays too rapidly. In this article, sweep imaging with Fourier transformation (SWIFT) sequence is combined with the Look-Locker method to map T1 of IONPs in high concentrations.
methodsT1 values of agar containing IONPs in different concentrations were measured with the SWIFT Look-Locker method and with inversion recovery spectroscopy. Precisions of Look-Locker and variable flip angle (VFA) methods were compared in simulations.
resultsThe measured R1 (=1/T1 ) has a linear relationship with IONP concentration up to 53.6 mM of Fe. This concentration exceeds concentrations measured in previous work by almost an order of magnitude. Simulations show SWIFT Look-Locker method is also much less sensitive to B1 inhomogeneity than the VFA method.
conclusionSWIFT Look-Locker can accurately measure T1 of IONP concentrations ≤53.6 mM. By mapping T1 as a function of IONP concentration, IONP distribution maps might be used in the future to plan effective magnetic nanoparticle hyperthermia therapy.
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