ArticleInfection and immunity2014
RTX toxin plays a key role in Kingella kingae virulence in an infant rat model.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- It is time to have a molecular test for diagnosingJournal of clinical microbiology · 2026Article
- Fastidious or rarely isolated gram-negative rods with a particular focus onClinical microbiology reviews · 2025Review
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- Identification of a Kingella kingae factor H binding protein that is the major determinant of serum resistance.PLoS pathogens · 2025Article
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- Infective Endocarditis Due toMicroorganisms · 2024Review
- Acquisition, co-option, and duplication of the rtx toxin system and the emergence of virulence in Kingella.Nature communications · 2023Article
- Whole-Genome Sequencing Reveals Differences among Kingella kingae Strains from Carriers and Patients with Invasive Infections.Microbiology spectrum · 2023Article
- Review
- Review
- Article
- Pathogenic determinants ofFrontiers in pediatrics · 2022Review
- Article
- Bacterial toxins in musculoskeletal infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Proinflammatory Microenvironment DuringFrontiers in immunology · 2021Article
- Fulminant Infective Endocarditis Due toFrontiers in pediatrics · 2021Article
- Binding ofInternational journal of molecular sciences · 2020Article
- [Early-onset septic shock in a preterm infant caused by Kingella Kingae].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Kingella kingae Surface Polysaccharides Promote Resistance to Neutrophil Phagocytosis and Killing.mBio · 2019Article
- Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding.Emerging microbes & infections · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Kingella kingae is a human oral bacterium that can cause diseases of the skeletal system in children and infective endocarditis in children and adults. K. kingae produces a toxin of the RTX group, RtxA. To investigate the role of RtxA in disease pathogenesis in vivo, K. kingae strain PYKK081 and its isogenic RtxA-deficient strain KKNB100 were tested for their virulence and pathological consequences upon intraperitoneal injections in 7-day-postnatal (PN 7) rats. At the doses above 8.0 × 10(6) cells/animal, PYKK081 was able to cause a fatal illness, resulting in rapid weight loss, bacteremia, and abdominal necrotic lesion formation. Significant histopathology was observed in thymus, spleen, and bone marrow. Strain KKNB100 was less toxic to animals. Neither weight loss, bacteremia, nor histopathological changes were evident. Animals injected with KKNB100 exhibited a significantly elevated circulating white blood cell (WBC) count, whereas animals injected with PYKK081 had a WBC count that resembled that of the uninfected control. This observation parallels the subtleties associated with clinical presentation of K. kingae disease in humans and suggests that the toxin contributes to WBC depletion. Thus, our results demonstrate that RtxA is a key K. kingae virulence factor. Furthermore, our findings suggest that the PN 7 rat can serve as a useful model for understanding disease caused by K. kingae and for elucidating diagnostic parameters in human patients.
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