Evidence map›Paper›PMID 24664486›Full record

ReviewThe oncologist2014

Implications of functional proteomics in breast cancer.

Young Kwang Chae, Ana Maria Gonzalez-Angulo

Abstract readReview
In one paragraph

Review in The oncologist, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Young Kwang ChaeDivision of Cancer Medicine and Departments of Breast Medical Oncology and Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ana Maria Gonzalez-Angulo

Funding

The PI3K/PTEN/AKT Signal Transduction Cascade in Breast CancerK23CA121994 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GONZALEZ-ANGULO, ANA M. · 2006 to 2010
$680k
NCI NIH HHS 1K23CA121994NCI NIH HHS K23 CA121994
6 · The paper itself

Abstract

Breast cancer is one of the major public health problems of the Western world. Recent advances in genomics and gene expression-profiling approaches have enriched our understanding of this heterogeneous disease. However, progress in functional proteomics in breast cancer research has been relatively slow. Allied with genomics, the functional proteomics approach will be important in improving diagnosis through better classification of breast cancer and in predicting prognosis and response to different therapies, including chemotherapy, hormonal therapy, and targeted therapy. In this review, we will present functional proteomic approaches with a focus on the recent clinical implications of utilizing the reverse-phase protein array platform in breast cancer research.

Indexed as

Biomarkers, TumorBreast NeoplasmsDrug DiscoveryFemaleGene Expression ProfilingHigh-Throughput Screening AssaysHumansPrognosisProtein Array AnalysisProteomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiomarkers, TumorBreast cancerFunctional proteomicsPredictive markerPrognostic marker

Identifiers

PMID24664486
PMCPMC3983827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.