ArticleDigestive diseases and sciences2014
Contrast-enhanced harmonic endoscopic ultrasonography in the differential diagnosis of gallbladder wall thickening.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Meta-analysis of contrast-enhanced ultrasound and contrast-enhanced harmonic endoscopic ultrasound for the diagnosis of gallbladder malignancy.BMC medical informatics and decision making · 2020Pooled it
- Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Role of Endoscopic Ultrasonography in Management of Pancreaticobiliary Cancers: Recent Trends and Advances.Cancers · 2026Review
- Efficacy of Contrast-Enhanced Endoscopic Ultrasound in the Diagnosis of Gallbladder Tumor: A Retrospective Multicenter Cohort Study.Journal of hepato-biliary-pancreatic sciences · 2026Article
- Practical approach to linear endoscopic ultrasound examination of the gallbladder.World journal of radiology · 2024Review
- Contrast-enhanced guided endoscopic ultrasound procedures.World journal of gastroenterology · 2024Review
- Recent Advances in Endoscopic Ultrasound for Gallbladder Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2024Review
- The role of contrast-enhanced endoscopic ultrasound for biliary diseases.Journal of medical ultrasonics (2001) · 2023Review
- The usefulness of endoscopic ultrasound in the diagnosis of gallbladder lesions.Frontiers in medicine · 2022Review
- A Novel Endoscopic Ultrasonography Imaging Technique for Depicting Microcirculation in Pancreatobiliary Lesions without the Need for Contrast-Enhancement: A Prospective Exploratory Study.Diagnostics (Basel, Switzerland) · 2021Article
- The Role of Contrast-Enhanced Harmonic Endoscopic Ultrasound in Interventional Endoscopic Ultrasound.Medicina (Kaunas, Lithuania) · 2021Review
- The Role of Endoscopic Ultrasound in the Diagnosis of Gallbladder Lesions.Diagnostics (Basel, Switzerland) · 2021Review
- A simple method for diagnosing gallbladder malignant tumors with subserosa invasion by endoscopic ultrasonography.BMC cancer · 2021Article
- Interobserver Reliability of Endoscopic Ultrasonography: Literature Review.Diagnostics (Basel, Switzerland) · 2020Review
- The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid.Ultrasonography (Seoul, Korea) · 2020Article
- Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases.World journal of gastroenterology · 2020Review
- Diagnostic Endoscopic Ultrasound: Technique, Current Status and Future Directions.Gut and liver · 2018Review
- CT diagnosis of gallbladder adenomyomatosis: importance of enhancing mucosal epithelium, the "cotton ball sign".European radiology · 2018Article
- A case of successful transluminal drainage of walled-off necrosis under contrast-enhanced harmonic endoscopic ultrasonography guidance.Journal of medical ultrasonics (2001) · 2018Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsDifferentiation of gallbladder (GB) carcinoma from benign GB wall thickening is challenging. The recent introduction of second-generation ultrasonic contrast agents has made contrast harmonic imaging with EUS possible. The aim of our study was to evaluate the utility of contrast-enhanced harmonic EUS (CH-EUS) for the differential diagnosis of GB wall thickening.
methodsThirty-six consecutive patients with GB wall thickening imaged by CH-EUS and then underwent surgery were enrolled in this study. After the lesions were observed with conventional harmonic EUS (H-EUS), CH-EUS was performed with intravenous injection of 0.015 ml/kg of Sonazoid. Three reviewers with various levels of experience of EUS (Reviewer A: experienced endosonographer, B: EUS trainee, C: experienced gastroenterologist with expertise in transabdominal ultrasound but no EUS experience) were blinded to findings of recorded video of H-EUS and CH-EUS. The diagnostic accuracy of H-EUS and CH-EUS for malignant GB wall thickening was compared.
resultsFinal diagnoses based on surgical histology were GB carcinoma in 16, cholecystitis in 11, adenomyomatosis in 6 and cholesterolosis in 3. Overall sensitivity, specificity and accuracy for diagnosing malignant GB wall thickening of H-EUS and CH-EUS were 83.3 versus 89.6, 65 versus 98% (p < 0.001) and 73.1 versus 94.4% (p < 0.001). The inter-observer agreement for H-EUS was moderate (κ = 0.51), whereas that for CH-EUS was substantial (κ = 0.77). The inhomogeneous enhanced pattern on CH-EUS was a strong predictive factor of malignant GB wall thickening.
conclusionCH-EUS has the potential to improve the preoperative diagnostic accuracy and inter-observer agreement in the differential diagnosis of GB wall thickening.
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