ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2014
The neurobiology of cancer pain.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05024383 (Dissecting the Heterogeneity of Oral Cancer Pain), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dissecting the Heterogeneity of Oral Cancer Pain
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Virtual reality in chemotherapy support for the treatment of physical functions, fear, and quality of life in pediatric cancer patients: A systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- New Technologies to Improve Pain, Anxiety and Depression in Children and Adolescents with Cancer: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- MMP1 and PRSS23 induce PARCommunications biology · 2026Article
- Ewing sarcoma-related pain: potential role of medical cannabis monotherapy in symptom management - a case report.Journal of cannabis research · 2026Article
- Review
- Energy Metabolism and Cancer Pain: A Pathway to Innovative Treatment Strategies.Current topics in medicinal chemistry · 2026Review
- Understanding the Physiopathology of Pain Pathways for a Practical Approach of Cancer Pain Management.Cardiovascular and interventional radiology · 2025Review
- Oral Cancer and Sleep Disturbances: A Narrative Review on Exploring the Bidirectional Relationship.Cancers · 2025Review
- Review
- PARBiomaterials · 2025Article
- Pain Management in Animals with Oncological Disease: Opioids as Influencers of Immune and Tumor Cellular Balance.Cancers · 2024Review
- Targeting TRPV4 Channels for Cancer Pain Relief.Cancers · 2024Review
- From pain to tumor immunity: influence of peripheral sensory neurons in cancer.Frontiers in immunology · 2024Review
- The neural addiction of cancer.Nature reviews. Cancer · 2023Review
- Genomic Interplay between Neoneurogenesis and Neoangiogenesis in Carcinogenesis: Therapeutic Interventions.Cancers · 2023Review
- Ozone in Chemotherapy-Induced Peripheral Neuropathy-Current State of Art, Possibilities, and Perspectives.International journal of molecular sciences · 2023Review
- Important Cells and Factors from Tumor Microenvironment Participated in Perineural Invasion.Cancers · 2023Review
- Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.Annual review of pharmacology and toxicology · 2023Review
- Oral cancer patients experience mechanical and chemical sensitivity at the site of the cancer.BMC cancer · 2022Article
- The Role of Schwann Cells in Cancer.Advanced biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The global burden of cancer pain is enormous and opioids, despite their side effects, remain the primary therapeutic approach. The cause of cancer pain is unknown. Mechanisms driving cancer pain differ from those mechanisms responsible for inflammatory and neuropathic pain. The prevailing hypothesis put forward to explain cancer pain posits that cancers generate and secrete mediators which sensitize and activate primary afferent nociceptors in the cancer microenvironment. Moreover, cancers induce neurochemical reorganization of the spinal cord, which contributes to spontaneous activity and enhanced responsiveness. The purpose of this review, which covers clinical and preclinical studies, is to highlight those peripheral and central mechanisms responsible for cancer pain. The challenges facing neuroscientists and clinicians studying and ultimately treating cancer pain are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.