ArticlePlant physiology2014
Hybridization alters spontaneous mutation rates in a parent-of-origin-dependent fashion in Arabidopsis.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Ancient Hybridisation Fuelled Diversification in Acropora Corals.Molecular ecology · 2025Article
- Diploid aposporous sunflower forms triploid BIII progeny displaying increased apospory levels and non-random genetic mutations.Scientific reports · 2025Article
- Phased genomics reveals hidden somatic mutations and provides insight into fruit development in sweet orange.Horticulture research · 2024Article
- The Genomic Shock Hypothesis: Genetic and Epigenetic Alterations of Transposable Elements after Interspecific Hybridization in Plants.Epigenomes · 2023Review
- New Insights into the Genomic Structure ofPlants (Basel, Switzerland) · 2022Article
- Genetic diversity and population structure of rice (Oryza sativa L.) landraces from Kerala, India analyzed through genotyping-by-sequencing.Molecular genetics and genomics : MGG · 2022Article
- Heterogeneous Mutation Rates and Spectra in Yeast Hybrids.Genome biology and evolution · 2021Article
- Epigenetics and the success of invasive plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair.Cells · 2021Review
- Discovery and Characterization of a Novel TomatoGenes · 2021Article
- Eukaryote hybrid genomes.PLoS genetics · 2019Article
- Effect of Hybridization on Somatic Mutations and Genomic Rearrangements in Plants.International journal of molecular sciences · 2018Review
- Amino acid compositions contribute to the proteins' evolution under the influence of their abundances and genomic GC content.Scientific reports · 2018Article
- Brief temperature stress during reproductive stages alters meiotic recombination and somatic mutation rates in the progeny of Arabidopsis.BMC plant biology · 2017Article
- Direct Determination of the Mutation Rate in the Bumblebee Reveals Evidence for Weak Recombination-Associated Mutation and an Approximate Rate Constancy in Insects.Molecular biology and evolution · 2017Article
- Mutation rate analysis via parent-progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids.Proceedings. Biological sciences · 2016Article
- Suppression of different classes of somatic mutations in Arabidopsis by vir gene-expressing Agrobacterium strains.BMC plant biology · 2015Article
- Parental age affects somatic mutation rates in the progeny of flowering plants.Plant physiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 70 years ago, increased spontaneous mutation rates were observed in Drosophila spp. hybrids, but the genetic basis of this phenomenon is not well understood. The model plant Arabidopsis (Arabidopsis thaliana) offers unique opportunities to study the types of mutations induced upon hybridization and the frequency of their occurrence. Understanding the mutational effects of hybridization is important, as many crop plants are grown as hybrids. Besides, hybridization is important for speciation and its effects on genome integrity could be critical, as chromosomal rearrangements can lead to reproductive isolation. We examined the rates of hybridization-induced point and frameshift mutations as well as homologous recombination events in intraspecific Arabidopsis hybrids using a set of transgenic mutation detector lines that carry mutated or truncated versions of a reporter gene. We found that hybridization alters the frequency of different kinds of mutations. In general, Columbia (Col)×Cape Verde Islands and Col×C24 hybrid progeny had decreased T→G and T→A transversion rates but an increased C→T transition rate. Significant changes in frameshift mutation rates were also observed in some hybrids. In Col×C24 hybrids, there is a trend for increased homologous recombination rates, except for the hybrids from one line, while in Col×Cape Verde Islands hybrids, this rate is decreased. The overall genetic distance of the parents had no influence on mutation rates in the progeny, as closely related accessions on occasion displayed higher mutation rates than accessions that are separated farther apart. However, reciprocal hybrids had significantly different mutation rates, suggesting parent-of-origin-dependent effects on the mutation frequency.
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