ArticlePediatric nephrology (Berlin, Germany)2014
Neurological involvement in children with E. coli O104:H4-induced hemolytic uremic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Acute neurologic clinical manifestations and outcomes in children with thrombotic microangiopathies in paediatric intensive care units.European journal of pediatrics · 2026Observational
- Neurological Manifestations of Hemolytic Uremic Syndrome: A Comprehensive Review.Brain sciences · 2025Review
- Eculizumab in STEC-HUS: a paradigm shift in the management of pediatric patients with neurological involvement.Pediatric nephrology (Berlin, Germany) · 2024Article
- Pharmacological Management of Atypical Hemolytic Uremic Syndrome in Pediatric Patients: Current and Future.Paediatric drugs · 2023Article
- Neurological involvement in children with hemolytic uremic syndrome.European journal of pediatrics · 2022Article
- Article
- Frequency of neurological involvement in patients with/without diarrhea hemolytic uremic syndrome: A Systematic review and meta-analysis.Medical journal of the Islamic Republic of Iran · 2021Article
- Alternating hemiparesis in the context of hemolytic uremic syndrome and COVID-19 positivity.Epilepsy & behavior reports · 2021Article
- Extrarenal manifestations of the hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC HUS).Pediatric nephrology (Berlin, Germany) · 2019Review
- Roles of Shiga Toxins in Immunopathology.Toxins · 2019Review
- Is eculizumab efficacious in Shigatoxin-associated hemolytic uremic syndrome? A narrative review of current evidence.European journal of pediatrics · 2018Review
- Public Health Research Resulting from One of the World's Largest Outbreaks Caused by Entero-HemorrhagicFrontiers in public health · 2017Review
- Hemolytic uremic syndrome associated with Escherichia coli O157:H7 infection in older adults: a case report and review of the literature.Journal of medical case reports · 2016Review
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- Article
- Neurodevelopmental long-term outcome in children after hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- A diagnosis of haemolytic-uraemic syndrome blurred by alcohol abuse.BMJ case reports · 2014Article
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Authors and funding
17 authors.
Funding
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Abstract
backgroundThe aim of this study was to analyze the neurological involvement and outcome in pediatric patients with hemolytic uremic syndrome (HUS) during the 2011 epidemic caused by Escherichia coli O104:H4.
methodsClinical data and data from magnetic resonance imaging (MRI) scans and electroencephalography (EEG) during the acute phase of the disease and during follow-up at 3 and 6 months were analyzed in 50 patients. Twenty-five of these patients underwent neuropsychological testing (WISC IV) during follow-up.
resultsNeurological involvement (stupor or coma, seizures, visual disturbances, paresis, myocloni) was initially observed in 14/50 (28%) patients. One patient died. EEG abnormalities were more frequent in patients with neurological involvement than in those without (12/14 vs. 13/25, respectively). Cranial MRI scans were analyzed in nine patients with neurological involvement, of whom five showed abnormal findings. At the 3- and 6-month follow-ups, EEG abnormalities were found in 14/40 (35%) and 7/36 (19%) patients, respectively, whereas 28/42 (67%) and 17/39 (44%) patients, respectively, complained about on-going reduced performance. Neuropsychological testing showed a slightly lower global intelligence quotient in patients with neurological involvement versus those without (113.4 ± 2.8 vs. 119.4 ± 1.8, respectively).
conclusionsNeurological involvement was frequent in our cohort. Accordingly, the incidence of pathological EEG findings was high, even in patients without clinical signs of neurological involvement. Nevertheless, major neurological sequelae were rare, and neuropsychological outcome was favorable after 6 months.
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