ArticleIntensive care medicine2014
Blood glucose level and outcome after cardiac arrest: insights from a large registry in the hypothermia era.
Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Singapore Post-cardiac Arrest Care Guidelines 2026.Singapore medical journal · 2026Review
- Feeding the injured brain: nutrients, dose, timing, and monitoring.Intensive care medicine · 2026Review
- Optimizing infection management after cardiac arrest: addressing diagnostic uncertainty and therapeutic dilemmas-a narrative review.Journal of intensive care · 2026Review
- Association of Average Glucose and Glycemic Variability With 28-Day Mortality in Patients With Cardiac Arrest: A Retrospective Study.Journal of diabetes · 2025Article
- Blood glucose upon return of spontaneous circulation and neurological outcomes following out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
- Do diabetes and poor control of acute stress-related hyperglycemia increase the risk of ICU-acquired infections? A retrospective assessment in patients with septic shock.Annals of intensive care · 2025Article
- Interaction of Hypertension and Diabetes Mellitus on Post-Cardiac Arrest Treatments and Outcomes in Cancer Patients Following Out-of-Hospital Cardiac Arrest.Journal of clinical medicine · 2025Article
- The "SOOTEST-ICU" bundle for optimizing cerebral hypoxia and reperfusion to minimize brain injury after resuscitation from cardiac arrest.World journal of emergency medicine · 2025Article
- Machine learning derivation of two cardiac arrest subphenotypes with distinct responses to treatment.Journal of translational medicine · 2025Article
- Review
- Glucose control and outcomes in diabetic and nondiabetic patients treated with targeted temperature management after cardiac arrest.PloS one · 2024Observational
- Early Glycemic State and Outcomes of Neonates With Hypoxic-Ischemic Encephalopathy.Pediatrics · 2023Article
- Association between stress hyperglycemia on admission and unfavorable neurological outcome in OHCA patients receiving ECPR.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Dextrose Administration and Resuscitation Outcomes in Patients with Blood Sugar Less Than 150 mg/dL during Cardiopulmonary Resuscitation: An Observational Data Analysis.Journal of clinical medicine · 2023Article
- Association between Intra-Arrest Blood Glucose Level and Outcomes of Resuscitation at the Emergency Department: A Retrospective Study.Journal of clinical medicine · 2022Article
- Beyond return of spontaneous circulation: update on post-cardiac arrest management in the intensive care unit.Singapore medical journal · 2021Review
- High HbA1c is associated with decreased 6-month survival and poor outcomes after out-of-hospital cardiac arrest: a retrospective cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2020Article
- Risks According to the Timing and Frequency of Hypotension Episodes in Postanoxic Comatose Patients.Journal of clinical medicine · 2020Article
- Observational
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe influence of blood glucose (BG) level during the post-resuscitation period after out-of-hospital cardiac arrest (OHCA) is still debated. To evaluate the relationship between blood glucose level and outcome, we included the median glycemia and its maximal amplitude over the first 48 h following ICU admission in an analysis of outcome predictors.
methodsWe conducted a database study in a cardiac arrest center in Paris, France. Between 2006 and 2010, we included 381 patients who were all resuscitated from an OHCA. A moderate glycemic control was applied in all patients. The median glycemia and the largest change over the first 48 h were included in a multivariate analysis that was performed to determine parameters associated with a favorable outcome.
resultsOf the 381 patients, 136 (36 %) had a favorable outcome (CPC 1-2). Median BG level was 7.6 mmol/L (6.3-9.8) in patients with a favorable outcome compared to 9.0 mmol/L (IQR 7.1-10.6) for patients with an unfavorable outcome (p < 0.01). Median BG level variation was 7.1 (4.2-11) and 9.6 (5.9-13.6) mmol/L in patients with and without a favorable outcome, respectively (p < 0.01). In multivariate analysis, an increased median BG level over the first 48 h was found to be an independent predictor of poor issue [OR = 0.43; 95 % CI (0.24-0.78), p = 0.006]. Finally a progressive increase in median BG level was associated with a progressive increase in the proportion of patients with a poor outcome.
conclusionWe observed a relationship between high blood glucose level and outcome after cardiac arrest. These results suggest the need to test a strategy combining both control of glycemia and minimization of glycemic variations for its ability to improve post-resuscitation care.
Indexed as
Identifiers
24664154What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.