ArticlePloS one2014
Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- The physiology of leptin in avians: A review.Poultry science · 2026Review
- Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity.Function (Oxford, England) · 2026Review
- A chromosome-level genome assembly for the Silkie chicken resolves complete sequences for key chicken metabolic, reproductive, and immunity genes.Communications biology · 2023Article
- Seasonal and sexual variation in mRNA expression of selected adipokine genes affecting fat deposition and metabolism of the emu (Dromaius novaehollandiae).Scientific reports · 2022Article
- Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022Review
- Leptin administration does not influence migratory behaviour in white-throated sparrows (PeerJ · 2022Article
- Expression of lysine-mediated neuropeptide hormones controlling satiety and appetite in broiler chickens.Poultry science · 2020Article
- Should I Lay or Should I Grow: Photoperiodic Versus Metabolic Cues in Chickens.Frontiers in physiology · 2020Review
- Avian Expression Patterns and Genomic Mapping Implicate Leptin in Digestion and TNF in Immunity, Suggesting That Their Interacting Adipokine Role Has Been Acquired Only in MammalsInternational journal of molecular sciences · 2019Article
- Plasma mammalian leptin analogue predicts reproductive phenology, but not reproductive output in a capital-income breeding seaduck.Ecology and evolution · 2019Article
- Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.Nature ecology & evolution · 2018Article
- Peripherally injected ghrelin and leptin reduce food hoarding and mass gain in the coal tit (Proceedings. Biological sciences · 2018Article
- Comparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction.BMC genomics · 2018Article
- Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases.International journal of endocrinology · 2018Review
- Influence of leptin and GABAJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Ghrelin affects stopover decisions and food intake in a long-distance migrant.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Energy Homeostasis in Monotremes.Frontiers in neuroscience · 2017Review
- Regulation of Agouti-Related Protein and Pro-Opiomelanocortin Gene Expression in the Avian Arcuate Nucleus.Frontiers in endocrinology · 2017Review
- On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin.Frontiers in endocrinology · 2017Article
- Leptin Induces Mitosis and Activates the Canonical Wnt/β-Catenin Signaling Pathway in Neurogenic Regions ofFrontiers in endocrinology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial. Here we identify leptin sequence from the Peregrine falcon, Falco peregrinus (pfleptin), and identify sequences from two other birds (mallard and zebra finch), and 'missing' vertebrates (elephant shark, alligator, Indian python, Chinese soft-shelled turtle, and coelacanth). The pattern of genes surrounding leptin (snd1, rbm28) is syntenic between the falcon and mammalian genomes. Phylogenetic analysis of all known leptin protein sequences improves our understanding of leptin's evolution. Structural modeling of leptin orthologs highlights a highly conserved hydrophobic core in the four-helix cytokine packing domain. A docked model of leptin with the leptin receptor for Peregrine falcon reveals several conserved amino acids important for the interaction and possible coevolution of leptin with its receptor. We also show for the first time, an authentic avian leptin sequence that activates the JAK-STAT signaling pathway. These newly identified sequences, structures, and tools for avian leptin and its receptor will allow elucidation of the function of these proteins in feral and domestic birds.
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