Trial reportPloS one2014
How well do discharge diagnoses identify hospitalised patients with community-acquired infections?--a validation study.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Empagliflozin Versus Dapagliflozin and Urogenital Adverse Events in Type 2 Diabetes: A Target Trial Emulation.Diabetes, obesity & metabolism · 2026Article
- Serious Infections in Offspring Exposed to Tumor Necrosis Factor Inhibitors During Pregnancy: Comparison of Timing During Pregnancy and Placental Transfer Ability.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Antibiotic Use in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Multicenter Retrospective Cohort Study.Journal of general internal medicine · 2026Article
- Serious adverse events, readmission, and mortality after shoulder replacement due to fracture, osteoarthritis, and other indications: a population-based comparison with the general population.Acta orthopaedica · 2025Article
- Temporal trends in socioeconomic inequalities and risk of infection after hip fracture surgery: a nationwide cohort study, 2010-2021.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes: a Danish 12 year cohort study.Diabetologia · 2025Article
- Incidence and Risk Factors for Varicella-Zoster Virus-Associated Central Nervous System Infections: A Nationwide Swedish Retrospective Case-Control Study.Journal of medical virology · 2025Article
- The Association Between Socioeconomic Position and Infection Risk After Hip Fracture Surgery: A Nationwide Cohort Study of 54,853 Patients.Clinical epidemiology · 2025Article
- Major comorbid diseases as predictors of infection in the first month after hip fracture surgery: a population-based cohort study in 92,239 patients.European geriatric medicine · 2024Article
- Use of antibiotics for urinary tract infections up to and after care home admission in Denmark: a nationwide study.European geriatric medicine · 2024Article
- Best Practices for Identifying Hospitalized Lower Respiratory Tract Infections Using Administrative Data: A Systematic Literature Review of Validation Studies.Infectious diseases and therapy · 2024Review
- Risk of serious infections in multiple sclerosis patients by disease course and disability status: Results from a Swedish register-based study.Brain, behavior, & immunity - health · 2022Article
- Article
- Two-fold risk of pneumonia and respiratory mortality in individuals with myeloproliferative neoplasm: A population-based cohort study.EClinicalMedicine · 2020Article
- A Single-Center Prospective Cohort Study on Postsplenectomy Sepsis and its Prevention.Open forum infectious diseases · 2020Article
- Prevalence, Characteristics, and Epidemiology of Microbial Hand Contamination Among Minnesota State Fair Attendees (2014).Frontiers in public health · 2020Article
- Posttraumatic Stress Disorder and Incident Infections: A Nationwide Cohort Study.Epidemiology (Cambridge, Mass.) · 2019Article
- Dispatch and prehospital transport for acute septic patients: an observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2017Observational
- Acute kidney injury as an independent risk factor for unplanned 90-day hospital readmissions.BMC nephrology · 2017Article
- Cerebrospinal fluid pleocytosis level as a diagnostic predictor? A cross-sectional study.BMC clinical pathology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCredible measures of disease incidence, trends and mortality can be obtained through surveillance using manual chart review, but this is both time-consuming and expensive. ICD-10 discharge diagnoses are used as surrogate markers of infection, but knowledge on the validity of infections in general is sparse. The aim of the study was to determine how well ICD-10 discharge diagnoses identify patients with community-acquired infections in a medical emergency department (ED), overall and related to sites of infection and patient characteristics.
methodsWe manually reviewed 5977 patients admitted to a medical ED in a one-year period (September 2010-August 2011), to establish if they were hospitalised with community-acquired infection. Using the manual review as gold standard, we calculated the sensitivity, specificity, predictive values, and likelihood ratios of discharge diagnoses indicating infection.
resultsTwo thousand five hundred eleven patients were identified with community-acquired infection according to chart review (42.0%, 95% confidence interval [95%CI]: 40.8-43.3%) compared to 2550 patients identified by ICD-10 diagnoses (42.8%, 95%CI: 41.6-44.1%). Sensitivity of the ICD-10 diagnoses was 79.9% (95%CI: 78.1-81.3%), specificity 83.9% (95%CI: 82.6-85.1%), positive likelihood ratio 4.95 (95%CI: 4.58-5.36) and negative likelihood ratio 0.24 (95%CI: 0.22-0.26). The two most common sites of infection, the lower respiratory tract and urinary tract, had positive likelihood ratios of 8.3 (95%CI: 7.5-9.2) and 11.3 (95%CI: 10.2-12.9) respectively. We identified significant variation in diagnostic validity related to age, comorbidity and disease severity.
conclusionICD-10 discharge diagnoses identify specific sites of infection with a high degree of validity, but only a moderate degree when identifying infections in general.
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