Evidence map›Paper›PMID 24663222›Full record

ReviewNature reviews. Endocrinology2014

Insulin resistance and hyperglycaemia in cardiovascular disease development.

Markku Laakso, Johanna Kuusisto

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06674161 (The Impact of Type 2 Diabetes Mellitus on Cardiovascular Events in Saudi Arabia Now and Future), which is not on this map. Cited by 477 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
477citing papers in PubMed, 9 pooled it
23.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06674161 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

The Impact of Type 2 Diabetes Mellitus on Cardiovascular Events in Saudi Arabia Now and Future

TypeobservationalSponsorKing Faisal Specialist Hospital & Research CenterRan2024 to 2030Enrolled80ConditionsMortality of Patients with CVD, Mortality of Patients with CVD and T2DM, Mortality of Patients with T2DM, Mortality of Patients with Neither
3 · Its place in the literature

Who cites it

477 citing papers in PubMed, 9 syntheses or guidelines pooled it, 904 citations in OpenAlex.

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417 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Markku LaaksoInstitute of Clinical Science, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Yliopistonranta 1E, 70210 Kuopio, Finland.
Johanna KuusistoInstitute of Clinical Science, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Yliopistonranta 1E, 70210 Kuopio, Finland.
University of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of diabetes mellitus will likely increase globally from 371 million individuals in 2013 to 552 million individuals in 2030. This epidemic is mainly attributable to type 2 diabetes mellitus (T2DM), which represents about 90-95% of all cases. Cardiovascular disease is the leading cause of mortality among individuals with diabetes mellitus, and >50% of patients will die from a cardiovascular event-especially coronary artery disease, but also stroke and peripheral vascular disease. Classic risk factors such as elevated levels of LDL cholesterol and blood pressure, as well as smoking, are risk factors for adverse cardiovascular events in patients with type 1 diabetes mellitus (T1DM) and T2DM to a similar degree as they are in healthy individuals. Patients with T1DM develop insulin resistance in the months after diabetes mellitus diagnosis, and patients with T2DM typically develop insulin resistance before hyperglycaemia occurs. Insulin resistance and hyperglycaemia, in turn, further increase the risk of adverse cardiovascular events. This Review discusses the mechanisms by which T1DM and T2DM can lead to cardiovascular disease and how these relate to the risk factors for coronary artery disease.

Indexed as

AnimalsBiomarkersCardiovascular DiseasesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2HumansHyperglycemiaInsulin ResistanceRisk FactorsVascular DiseasesBiomarkers

Identifiers

PMID24663222
OpenAlexW2053091858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.