Evidence map›Paper›PMID 24662826›Full record

ArticleOncogene2015

Slug is temporally regulated by cyclin E in cell cycle and controls genome stability.

W-L Wang, H-C Huang, S-H Kao, Y-C Hsu, Y-T Wang, K-C Li, Y-J Chen, S-L Yu, S-P Wang, T-H Hsiao and 2 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. pSlugVirchows Archiv : an international journal of pathology · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. An NADiScience · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

W-L Wang1] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan [2] Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.
H-C HuangInstitute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan.
S-H Kao1] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan [2] Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Y-C HsuInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Y-T Wang1] Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan [2] Institute of Chemistry, Academia Sinica, Taipei, Taiwan.
K-C LiInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Y-J Chen1] Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan [2] Institute of Chemistry, Academia Sinica, Taipei, Taiwan.
S-L YuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
S-P WangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
T-H HsiaoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
P-C Yang1] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan [2] Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan [3] NTU Center of Genomic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
T-M HongInstitute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.
Institute of Biomedical Sciences, Academia Sinica · TWAcademia Sinica · TWInstitute of Statistical Science, Academia Sinica · TWNational Taiwan University · TWNational Taiwan University Hospital · TWNational Cheng Kung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptional repressor Slug is best known to control epithelial-mesenchymal transition (EMT) and promote cancer invasion/metastasis. In this study, we demonstrate that Slug is temporally regulated during cell cycle progression. At G1/S transition, cyclin E-cyclin-dependent kinase 2 mediates the phosphorylation of Slug at Ser-54 and Ser-104, resulting in its ubiquitylation and degradation. Non-phosphorylatable Slug is markedly stabilized at G1/S transition compared with wild-type Slug and greatly leads to downregulation of DNA synthesis and checkpoint-related proteins, including TOP1, DNA Ligase IV and Rad17, reduces cell proliferation, delays S-phase progression and contributes to genome instability. Our results indicate that Slug has multifaceted roles in cancer progression by controlling both EMT and genome stability.

Indexed as

Cell CycleGenomic InstabilityCell Line, TumorCell ProliferationCyclin-Dependent Kinase 2Cyclin EEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHEK293 CellsHeLa CellsHumansLeupeptinsNeoplasmsPhosphorylationSnail Family Transcription FactorsTranscription Factorsbenzyloxycarbonylleucyl-leucyl-leucine aldehydeCDK2 protein, humanCyclin-Dependent Kinase 2Cyclin ELeupeptinsSNAI1 protein, humanSnail Family Transcription FactorsTranscription Factors

Identifiers

PMID24662826
OpenAlexW1990065140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.