ArticleNature communications2014
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- A Disintegrin and Metalloproteinase 10 Regulates Ephrin B2-Mediated Endothelial Cell Sprouting and Ischemic Retinopathy.The American journal of pathology · 2025Article
- Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling.Nature communications · 2023Article
- Article
- Assays for Apical Constriction Using the Xenopus Model.Methods in molecular biology (Clifton, N.J.) · 2022Article
- EphrinB2-EphB2 signaling for dendrite protection after neuronal ischemiaJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer.Cancer research · 2021Article
- ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease.International journal of molecular sciences · 2021Review
- Rab11fip5 regulates telencephalon development via ephrinB1 recycling.Development (Cambridge, England) · 2021Article
- The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis.Scientific reports · 2021Article
- [Research progress on the expression and function of erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins in oral-related diseases].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Review
- Essential roles of EphrinB2 in mammalian heart: from development to diseases.Cell communication and signaling : CCS · 2019Review
- Therapeutic potential of targeting the Eph/ephrin signaling complex.The international journal of biochemistry & cell biology · 2018Review
- Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor.Scientific reports · 2018Article
- TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration.Nature communications · 2018Article
- Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway.American journal of translational research · 2018Article
- ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.Nature medicine · 2017Article
- Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells.Oncotarget · 2017Article
- A frog's view of EphrinB signaling.Genesis (New York, N.Y. : 2000) · 2017Review
- Mechanisms of ephrin-Eph signalling in development, physiology and disease.Nature reviews. Molecular cell biology · 2016Review
- T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression.Cell reports · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The Eph/ephrin signalling pathways have a critical function in cell adhesion and repulsion, and thus play key roles in various morphogenetic events during development. Here we show that a decrease in ephrinB2 protein causes neural tube closure defects during Xenopus laevis embryogenesis. Such a decrease in ephrinB2 protein levels is observed on the loss of flotillin-1 scaffold protein, a newly identified ephrinB2-binding partner. This dramatic decline in ephrinB2 protein levels on the absence of flotillin-1 expression is specific, and is partly the result of an increased susceptibility to cleavage by the metalloprotease ADAM10. These findings indicate that flotillin-1 regulates ephrinB2 protein levels through ADAM10, and is required for appropriate neural tube morphogenesis in the Xenopus embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.