ArticleViruses2014
Retrospective serology study of respiratory virus infections in captive great apes.
Article in Viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Avian Metapneumovirus: Virology, Epidemiology, and Insights from a Comparative Analysis with Human Metapneumovirus-A Review.Biomolecules · 2026Review
- Review
- Low-doseFrontiers in immunology · 2024Article
- A comprehensive review of influenza B virus, its biological and clinical aspects.Frontiers in microbiology · 2024Review
- Review
- Fungal Rhinosinusitis Caused by aPathogens (Basel, Switzerland) · 2022Article
- Genetic adaptations to SIV across chimpanzee populations.PLoS genetics · 2022Article
- Review
- Evidence of Influenza A Virus Infection in Cynomolgus Macaques, Thailand.Veterinary sciences · 2022Article
- Reverse Zoonosis of COVID-19: Lessons From the 2009 Influenza Pandemic.Veterinary pathology · 2021Review
- Human Respiratory Syncytial Virus Detected in Mountain Gorilla Respiratory Outbreaks.EcoHealth · 2020Article
- Selective usage of ANP32 proteins by influenza B virus polymerase: Implications in determination of host range.PLoS pathogens · 2020Article
- Acute human orthopneumovirus infection in a captive white-handed gibbon.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- Risk factors for respiratory illness in a community of wild chimpanzees (Royal Society open science · 2018Article
- Pathogen Transmission from Humans to Great Apes is a Growing Threat to Primate Conservation.EcoHealth · 2018Review
- Detection of HEV-specific antibodies in four non-human primate species, including great apes, from different zoos in Germany.Epidemiology and infection · 2018Article
- Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.EMBO reports · 2016Article
- Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak.EcoHealth · 2016Article
- Genome-Wide Analysis of Human Metapneumovirus Evolution.PloS one · 2016Article
- The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.Antiviral research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Great apes are extremely sensitive to infections with human respiratory viruses. In this study, we retrospectively analyzed sera from captive chimpanzees, gorillas and orang-utans. More than 1000 sera (403 chimpanzee, 77 gorilla, and 535 orang-utan sera) were analyzed for antibodies to the human respiratory viruses RSV (respiratory syncytial virus, hMPV (human metapneumovirus), H1N1 and H3N2 influenza A viruses, and influenza B virus. In all ape species high seroprevalences were found for RSV, hMPV, and influenza B virus. A high percentage of captive chimpanzees also showed evidence of influenza A H1N1 infections, and had low levels of H3N2 antibodies, while in sera from gorillas and orangutans antibody levels to influenza A and B viruses were much lower or practically absent. Transmission of respiratory viruses was examined in longitudinal sera of young chimpanzees, and in chimpanzee sera taken during health checks. In young animals isolated cases of influenza infections were monitored, but evidence was found for single introductions followed by a rapid dissemination of RSV and hMPV within the group. Implementation of strict guidelines for handling and housing of nonhuman primates was shown to be an efficient method to reduce the introduction of respiratory infections in colonies of captive animals. RSV seroprevalence rates of chimpanzees remained high, probably due to circulating virus in the chimpanzee colony.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.